EPZ004777

目录号: A12983

DOT1L inhibitor

EPZ004777

EPZ004777 Chemical Structure

CAS NO. 1338466-77-5

EPZ004777 is a potent, selective inhibitor of DOT1L. EPZ004777 selectively inhibits cellular H3K79 methylation and inhibits expression of key MLL fusion target genes.

库存: 现货

规格 价格 数量
5 mg
¥ 1,100.00
10 mg
¥ 1,900.00
25 mg
¥ 2,900.00
50 mg
¥ 5,500.00
10mM * 1mL in DMSO
¥ 1,310.00
Warning 产品仅用于科学研究,不针对患者销售,望谅解.

详情

EPZ004777 is a potent, selective inhibitor of DOT1L. EPZ004777 selectively inhibits cellular H3K79 methylation and inhibits expression of key MLL fusion target genes.
Targets
DOT1L (Cell-free assay)
0.4 nM
In vitro DMSO 100 mg/mL (185.29 mM)
Water <1 mg/mL (<1 mM)
Ethanol 100 mg/mL (185.29 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 18.53 mL 92.65 mL 185.3 mL
0.5 mM 3.71 mL 18.53 mL 37.06 mL
1 mM 1.85 mL 9.26 mL 18.53 mL
5 mM 0.37 mL 1.85 mL 3.71 mL

*The above data is based on the productmolecular weight 539.67. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

目录号 A12983
MECHANISM OF ACTION Inhibitor
M. Wt 539.67
Formula C28H41N7O4
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 1338466-77-5
Synonyms EPZ 004777, EPZ-004777
SMILES CC(C)N(CCCNC(=O)NC1=CC=C(C=C1)C(C)(C)C)C[C@@H]2[C@H]([C@H]([C@@H](O2)N3C=CC4=C3N=CN=C4N)O)O

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