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EPZ004777

DOT1L 抑制剂

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产品目录号: A12983

库存状态:中国现货中国现货

产品名 目录号 价格 数量
EPZ004777 5mg A12983-5
¥ 1,100.00
EPZ004777 10mg A12983-10
¥ 1,900.00
EPZ004777 25mg A12983-25
¥ 2,900.00
EPZ004777 50mg A12983-50
¥ 5,500.00
EPZ004777 10mM * 1mL in DMSO A12983-10mM-D
¥ 1,310.00

产品仅用于研究,不针对患者销售,望谅解.

产品简介

EPZ004777 is a potent, selective inhibitor of DOT1L. EPZ004777 selectively inhibits cellular H3K79 methylation and inhibits expression of key MLL fusion target genes.

EPZ004777

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Chemical Information

目录号 A12983
Mechanism of action Inhibitor
分子量 539.67
化学分子式 C28H41N7O4
Solubility DMSO
纯度 >98%
储存方式 at -20°C 2 years
CAS No. 1338466-77-5
Synonyms EPZ 004777, EPZ-004777
SMILES code CC(C)N(CCCNC(=O)NC1=CC=C(C=C1)C(C)(C)C)C[C@@H]2[C@H]([C@H]([C@@H](O2)N3C=CC4=C3N=CN=C4N)O)O
化学名称 1-(3-((((2R,3S,4R,5R)-5-(4-amino-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl)(isopropyl)amino)propyl)-3-(4-(tert-butyl)phenyl)urea

生物活性

Description
EPZ004777 is a potent, selective inhibitor of DOT1L. EPZ004777 selectively inhibits cellular H3K79 methylation and inhibits expression of key MLL fusion target genes.
Targets
DOT1L (Cell-free assay)
0.4 nM

溶解性

Solubility (25°C)* In vitro DMSO 100 mg/mL (185.29 mM)
Water <1 mg/mL (<1 mM)
Ethanol 100 mg/mL (185.29 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 18.53 mL 92.65 mL 185.3mL
0.5 mM 3.71 mL 18.53 mL 37.06 mL
1 mM 1.85 mL 9.26 mL 18.53 mL
5 mM 0.37 mL 1.85 mL 3.71 mL

*The above data is based on the productmolecular weight 539.67. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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