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EPZ011989

EZH2 抑制剂

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产品目录号: A15544

库存状态:中国现货中国现货

产品名 目录号 价格 数量
EPZ011989 5mg A15544-5
¥ 800.00
EPZ011989 10mg A15544-10
¥ 1,400.00
EPZ011989 25mg A15544-25
¥ 8,000.00

产品仅用于研究,不针对患者销售,望谅解.

产品简介

EPZ011989 is a potent, selective orally bioavailable EZH2 inhibitor with Ki < 3 nM for EZH2 wt and EZH2 Y646; 15-fold selectivity over EZH1 and >3000-fold selectivity over other HMTase.

EPZ011989

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Chemical Information

目录号 A15544
Mechanism of action Inhibitor
分子量 605.81
化学分子式 C35H51N5O4
Solubility DMSO
纯度 >98%
储存方式 at -20°C 2 years
CAS No. 1598383-40-4
Synonyms EPZ-011989, EPZ 011989
SMILES code CCN(C1CCC(CC1)N(C)CCOC)C2=CC(=CC(=C2C)C(=O)NCC3=C(C=C(NC3=O)C)C)C#CCN4CCOCC4
化学名称 N-[(4,6-dimethyl-2-oxo-1H-pyridin-3-yl)methyl]-3-[ethyl-[4-[2-methoxyethyl(methyl)amino]cyclohexyl]amino]-2-methyl-5-(3-morpholin-4-ylprop-1-ynyl)benzamide

生物活性

Description
EPZ011989 is a potent, selective orally bioavailable EZH2 inhibitor with Ki < 3 nM for EZH2 wt and EZH2 Y646; 15-fold selectivity over EZH1 and >3000-fold selectivity over other HMTase.

制备储备液

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 16.51 mL 82.53 mL 165.07mL
0.5 mM 3.3 mL 16.51 mL 33.01 mL
1 mM 1.65 mL 8.25 mL 16.51 mL
5 mM 0.33 mL 1.65 mL 3.3 mL

*The above data is based on the productmolecular weight 605.81. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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