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EPZ011989是一种有效的，选择性的生物利用型EZH2抑制剂，对于EZH2 wt和EZH2 Y646，Ki <3 nM；选择性是EZH1的15倍，选择性是其他HMTase的3000倍。
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 16.51 mL | 82.53 mL | 165.07 mL |
| 0.5 mM | 3.3 mL | 16.51 mL | 33.01 mL |
| 1 mM | 1.65 mL | 8.25 mL | 16.51 mL |
| 5 mM | 0.33 mL | 1.65 mL | 3.3 mL |
*The above data is based on the productmolecular weight 605.81. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A15544 |
|---|---|
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 605.81 |
| Formula | C35H51N5O4 |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 1598383-40-4 |
| Synonyms | EPZ-011989, EPZ 011989 |
| SMILES | CCN(C1CCC(CC1)N(C)CCOC)C2=CC(=CC(=C2C)C(=O)NCC3=C(C=C(NC3=O)C)C)C#CCN4CCOCC4 |
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