Etoposide (VP-16)

目录号: A10373

Topoisomerase II inhibitor

Etoposide (VP-16) Chemical Structure

CAS NO. 33419-42-0

Etoposide forms a ternary complex with DNA and the topoisomerase II enzyme (which aids in DNA unwinding), prevents re-ligation of the DNA strands, and by doing so causes DNA strands to break. Therefore, this causes errors in DNA synthesis and promotes apoptosis of the cancer cell.

库存: 现货

规格 价格 数量
100 mg
¥ 500.00
500 mg
¥ 1,500.00
10mM * 1mL in DMSO
¥ 650.00
Warning 产品仅用于科学研究,不针对患者销售,望谅解.

详情

Etoposide forms a ternary complex with DNA and the topoisomerase II enzyme (which aids in DNA unwinding), prevents re-ligation of the DNA strands, and by doing so causes DNA strands to break. Therefore, this causes errors in DNA synthesis and promotes apoptosis of the cancer cell.
Targets
Topo II (Cell-free assay)
In vitro (25°C) DMSO 100 mg/mL (169.9 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 30% propylene glycol, 5% Tween 80, 65% D5W 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 16.99 mL 84.95 mL 169.89 mL
0.5 mM 3.4 mL 16.99 mL 33.98 mL
1 mM 1.7 mL 8.49 mL 16.99 mL
5 mM 0.34 mL 1.7 mL 3.4 mL

*The above data is based on the productmolecular weight 588.6. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

目录号 A10373
MECHANISM OF ACTION Inhibitor
M. Wt 588.6
Formula C29H32O13
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 33419-42-0
Synonyms VP16, Vepesid, etoposide phosphate
SMILES C[C@@H]1OC[C@@H]2[C@@H](O1)[C@@H]([C@H]([C@@H](O2)O[C@H]3[C@H]4COC(=O)[C@@H]4[C@@H](C5=CC6=C(C=C35)OCO6)C7=CC(=C(C(=C7)OC)O)OC)O)O

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