Etrolizumab, also known as rhuMAb Beta7, is a gut-selective monoclonal antibody that selectively targets the ??7 subunit of ??4??7 and ??E??7 integrins. This antibody demonstrates high affinity binding, with dissociation constants (Ki) of 18 nM for Human ??4??7 and 1.8 nM for Human ??E??7-293 integrins. Etrolizumab is primarily utilized in the research of inflammatory bowel diseases (IBD), making it a valuable tool for studies aimed at understanding and potentially treating these conditions.
Etrolizumab, also known as rhuMAb Beta7, is a gut-selective monoclonal antibody that selectively targets the ??7 subunit of ??4??7 and ??E??7 integrins. This antibody demonstrates high affinity binding, with dissociation constants (Ki) of 18 nM for Human ??4??7 and 1.8 nM for Human ??E??7-293 integrins. Etrolizumab is primarily utilized in the research of inflammatory bowel diseases (IBD), making it a valuable tool for studies aimed at understanding and potentially treating these conditions.
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