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Everolimus (RAD001)


mTOR 抑制剂

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产品目录号: A10374


产品名 目录号 价格 数量
Everolimus 10mg A10374-10
¥ 600.00
Everolimus 25mg A10374-25
¥ 1,200.00
Everolimus 50mg A10374-50
¥ 2,000.00
Everolimus 100mg A10374-100
¥ 3,200.00
Everolimus (RAD001) 10mM * 1mL in DMSO A10374-10mM-D
¥ 1,160.00



Everolimus (RAD-001) is the 40-O-(2-hydroxyethyl) derivative of sirolimus and works similarly to sirolimus as an mTOR inhibitor.

Everolimus (RAD001)




顾客使用 Adooq 产品发表的高质量科研文献
Adooq 顾客使用 Everolimus (RAD001) 发表的文献 (4)
  • Hiroshi Fukamachi, .et al. A subset of diffuse-type gastric cancer is susceptible to mTOR inhibitors and checkpoint inhibitors, J Exp Clin Cancer Res, 2019, 38:127
  • Nachi Namatame, .et al. Antitumor profile of the PI3K inhibitor ZSTK474 in human sarcoma cell lines, Oncotarget, 2018, Oct 12; 9(80): 35141每35161 PMID: 30416685
  • Hirosumi Tamura, .et al. Evaluation of anticancer agents using patient-derived tumor organoids characteristically similar to source tissues, Oncol Rep, 2018, Aug; 40(2): 635每646 PMID: 29917168
  • Rieko Ohki, .et al. PHLDA3 is a novel tumor suppressor of pancreatic neuroendocrine tumors, Proc Natl Acad Sci U S A., 2014, 111(23): E2404每E2413. PMID: 24912192

Chemical Information

目录号 A10374
Mechanism of action Inhibitor
分子量 958.2
化学分子式 C53H83NO14
Solubility DMSO
纯度 >98%
储存方式 at -20°C 2 years
CAS No. 159351-69-6
Synonyms SDZ-RAD, Certican, Zortress, Afinitor
SMILES code C[C@@H]1CC[C@H]2C[C@@H](/C(=C/C=C/C=C/[C@H](C[C@H](C(=O)[C@@H]([C@@H](/C(=C/[C@H](C(=O)C[C@H](OC(=O)[C@@H]3CCCCN3C(=O)C(=O)[C@@]1(O2)O)[C@H](C)C[C@@H]4CC[C@H]([C@@H](C4)OC)OCCO)C)/C)O)OC)C)C)/C)OC
化学名称 dihydroxy-12-[(2R)-1-[(1S,3R,4R)-4-(2-hydroxyethoxy)-3-methoxycyclohexyl]propan-2-yl]-19,30-dimethoxy-15,17,21,23,29,35-hexamethyl-11,36-dioxa-4-azatricyclo[,9]hexatriaconta-16,24,26,28-tetraene-2,3,10,14,20-pentone


Everolimus (RAD-001) is the 40-O-(2-hydroxyethyl) derivative of sirolimus and works similarly to sirolimus as an mTOR inhibitor.
mTOR (FKBP12) (Cell-free assay)
1.6 nM-2.4 nM


Solubility (25°C) * In vitro DMSO 30 mg/mL (31.3 mM)
Water <1 mg/mL (<1 mM)
Ethanol 7 mg/mL (7.3 mM)
In vivo 30% propylene glycol, 5% Tween 80, 65% D5W 5 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.


Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 10.44 mL 52.18 mL 104.36mL
0.5 mM 2.09 mL 10.44 mL 20.87 mL
1 mM 1.04 mL 5.22 mL 10.44 mL
5 mM 0.21 mL 1.04 mL 2.09 mL

*The above data is based on the productmolecular weight 958.2 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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