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ALK4/ALK5 抑制剂

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产品目录号: A14213


产品名 目录号 价格 数量
EW-7197 5mg A14213-5
¥ 1,300.00
EW-7197 10mg A14213-10
¥ 2,200.00
EW-7197 25mg A14213-25
¥ 4,400.00
EW-7197 10mM * 1mL in DMSO A14213-10mM-D
¥ 1,140.00



EW-7197 is a highly potent, selective, and orally bioavailable TGF-β I receptor ALK4/ALK5 inhibitor with IC50 of 13 nM and 11 nM, respectively





顾客使用 Adooq 产品发表的高质量科研文献
Adooq 顾客使用 EW-7197 发表的文献 (1)
  • Morita T, .et al. Tumor Progression Is Mediated by Thymosin-汕4 through a TGF汕/MRTF Signaling Axis, Mol Cancer Res, 2018, May;16(5):880-893 PMID: 29330296

Chemical Information

目录号 A14213
Mechanism of action Inhibitor
分子量 399.42
化学分子式 C22H18FN7
Solubility DMSO
纯度 >98%
储存方式 at -20°C 2 years
CAS No. 1352608-82-2
Synonyms EW7197
SMILES code CC1=CC=CC(=N1)C2=C(N=C(N2)CNC3=CC=CC=C3F)C4=CN5C(=NC=N5)C=C4
化学名称 N-(2-fluorophenyl)-5-(6-methyl-2-pyridinyl)-4-[1,2,4]triazolo[1,5-a]pyridin-6-yl-1H-imidazole-2-methanamine


EW-7197 is a highly potent, selective, and orally bioavailable TGF-β I receptor ALK4/ALK5 inhibitor with IC50 of 13 nM and 11 nM, respectively
Target Value
ALK5IC50: 11nM
ALK4IC50: 13nM
ALK1IC50: >10μM
ALK2IC50: >10μM
ALK3IC50: >10μM
ALK6IC50: >10μM


Solubility (25°C)* In vitro DMSO 79 mg/mL (197.78 mM)
Water <1 mg/mL (<1 mM)
Ethanol 43 mg/mL heating (107.65 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.


Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 25.04 mL 125.18 mL 250.36mL
0.5 mM 5.01 mL 25.04 mL 50.07 mL
1 mM 2.5 mL 12.52 mL 25.04 mL
5 mM 0.5 mL 2.5 mL 5.01 mL

*The above data is based on the productmolecular weight 399.42. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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