EW-7197

目录号: A14213

ALK4/ALK5 inhibitor

EW-7197

EW-7197 Chemical Structure

CAS NO. 1352608-82-2

EW-7197 is a highly potent, selective, and orally bioavailable TGF-β I receptor ALK4/ALK5 inhibitor with IC50 of 13 nM and 11 nM, respectively

库存: 现货

规格 价格 数量
5 mg
¥ 1,300.00
10 mg
¥ 2,200.00
25 mg
¥ 4,400.00
10mM * 1mL in DMSO
¥ 1,140.00
Warning 产品仅用于科学研究,不针对患者销售,望谅解.

详情

EW-7197 is a highly potent, selective, and orally bioavailable TGF-β I receptor ALK4/ALK5 inhibitor with IC50 of 13 nM and 11 nM, respectively
Targets
Target Value
ALK5IC50: 11nM
ALK4IC50: 13nM
ALK1IC50: >10μM
ALK2IC50: >10μM
ALK3IC50: >10μM
ALK6IC50: >10μM
In vitro DMSO 79 mg/mL (197.78 mM)
Water <1 mg/mL (<1 mM)
Ethanol 43 mg/mL heating (107.65 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 25.04 mL 125.18 mL 250.36 mL
0.5 mM 5.01 mL 25.04 mL 50.07 mL
1 mM 2.5 mL 12.52 mL 25.04 mL
5 mM 0.5 mL 2.5 mL 5.01 mL

*The above data is based on the productmolecular weight 399.42. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Technical Details

目录号 A14213
MECHANISM OF ACTION Inhibitor
M. Wt 399.42
Formula C22H18FN7
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 1352608-82-2
Synonyms EW7197
SMILES CC1=CC=CC(=N1)C2=C(N=C(N2)CNC3=CC=CC=C3F)C4=CN5C(=NC=N5)C=C4

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