EX 527 (Selisistat)

Name: EX 527 (Selisistat)
SKU: A10377
Price: 140 CNY
Rating: 5 (8 reviews)

目录号: A10377

SIRT1 抑制剂

8 篇发表文献

EX 527 是一种强效且选择性的 SIRT1 类 III 组蛋白去乙酰化酶 抑制剂，在无细胞试验中的 IC50 为 38 nM。

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Grouped product items
规格	价格	库存
5mg	¥140.00	现货
10mg	¥245.00	现货
25mg	¥455.00	现货
50mg	¥840.00	现货
100mg	¥1,365.00	现货
200mg	¥2,520.00	现货
500mg	¥4,130.00	现货
*10mM 1mL in DMSO**	¥280.00	现货
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重要通知：仅供研究使用。我们不向患者销售。

Data Sheet

SDS

顾客使用 Adooq 产品发表的高质量科研文献

Adooq用户使用EX 527 (Selisistat)发表的8篇文献

Yue He, .et al. , FASEB J, 2024, Oct 15;38(19):e70095 PMID: 39373984

Qiang Chen, .et al. , J Bioenerg Biomembr, 2022, Feb;55(1):33-42 PMID: 36525212

Flavien Bizot, .et al. , Mol Ther Nucleic Acids, 2022, Nov 21;30:606-620 PMID: 36514350

Takeshi Nakamura, .et al. , Shimane Journal of Medical Science, 2022, 38 (2), 59-66

Bugga Paramesha, .et al. , Antioxidants (Basel), 2021, Feb 24;10(3):338 PMID: 33668369

Wenhui Yao, .et al. , J Cell Physiol, 2020, 07 August

Guang Bai, .et al. , Epigenetics of Chronic Pain, 2019, Pages 1-48

Yoshikawa A, .et al. , J Neurochem, 2015, Feb;132(3):342-53 PMID: 25351847

生物活性

Discription

EX 527 is a potent and selective SIRT1 class III histone deacetylase enzyme inhibitor with IC50 of 38 nM in a cell-free assay.

Targets

Target	Value

Cell Research

Cell Line	Type	Value	Description	References

产品信息

目录号	A10377
分子式	C13H13ClN2O
分子量	248.7
CAS号	49843-98-3
SMILES	C1CC(C2=C(C1)C3=C(N2)C=CC(=C3)Cl)C(=O)N
储存条件	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

溶解性数据

In vitro (25°C)	DMSO	46 mg/mL (184.95 mM)
	Water	Insoluble
	Ethanol	17 mg/mL (68.35 mM)
In vivo	5% DMSO+30% PEG 300+ddH2O	14 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	40.21 mL	201.05 mL	402.09 mL
0.5 mM	8.04 mL	40.21 mL	80.42 mL
1 mM	4.02 mL	20.1 mL	40.21 mL
5 mM	0.8 mL	4.02 mL	8.04 mL

Useful Calculator

This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

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* Please check COA/MSDS for correct molecular weight.

Calculate the dilution required to prepare a stock solution.
This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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