Ezabenlimab (BI-754091) is a monoclonal antibody targeting the programmed death-1 (PD-1) receptor, exhibiting a binding affinity with a dissociation constant (Kd) of 6 nM, as determined in CHO cell assays. This antibody effectively inhibits the interaction between PD-1 and its ligands PD-L1 and PD-L2, thereby enhancing interferon-?? secretion in T cells. The blockade of this pathway by Ezabenlimab has demonstrated the ability to inhibit tumor growth in vivo, highlighting its potential utility in oncological research and therapeutic applications.
Ezabenlimab (BI-754091) is a monoclonal antibody targeting the programmed death-1 (PD-1) receptor, exhibiting a binding affinity with a dissociation constant (Kd) of 6 nM, as determined in CHO cell assays. This antibody effectively inhibits the interaction between PD-1 and its ligands PD-L1 and PD-L2, thereby enhancing interferon-?? secretion in T cells. The blockade of this pathway by Ezabenlimab has demonstrated the ability to inhibit tumor growth in vivo, highlighting its potential utility in oncological research and therapeutic applications.
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