F-1 | ALK and ROS1 dual inhibitor | 美国进口 | F-1 供应商 AdooQ®

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F-1

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生物活性

F-1 is a potent ALK and ROS1 dual inhibitor, suppresses phospho-ALK and its relative downstream signaling pathways, with IC50s of 2.1 nM, 2.3 nM, 1.3 nM and 3.9 nM for ALKWT, ROS1WT, ALKL1196M and ALKG1202R, respectively.

制备储备液

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	19.27 mL	96.34 mL	192.67 mL
0.5 mM	3.85 mL	19.27 mL	38.53 mL
1 mM	1.93 mL	9.63 mL	19.27 mL
5 mM	0.39 mL	1.93 mL	3.85 mL

*The above data is based on the productmolecular weight 519.02. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

化学数据

目录号	A19269
M. Wt	519.02
Formula	C22H27ClN8O3S
Purity	>99%
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
CAS No.	2244775-31-1
SMILES	O=S(NC1=C(NC2=NC(NC3=C(OC)N=C(N4CCN(C)CC4)C=C3)=NC=C2Cl)C=CC=C1)(C)=O

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