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Fasudil HCl (HA-1077)

促销

ROCK 抑制剂

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产品目录号: A10381

库存状态:中国现货中国现货

产品名 目录号 价格 数量
Fasudil HCl 250mg A10381-250
¥ 500.00
Fasudil HCl 500mg A10381-500
¥ 750.00

产品仅用于研究,不针对患者销售,望谅解.

产品简介

Fasudil HCl is a cyclic nucleotide-dependent protein kinase inhibitor and Rho-associated kinase inhibitor (IC50 = 10.7 μM).

Fasudil HCl (HA-1077)

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顾客使用 Adooq 产品发表的高质量科研文献
Adooq 顾客使用 Fasudil HCl (HA-1077) 发表的文献 (3)
  • Kumar M, .et al. Fasudil hydrochloride ameliorates memory deficits in rat model of streptozotocin-induced Alzheimer's disease: Involvement of PI3-kinase, eNOS and NF百B, Behav Brain Res, 2018, Oct 1;351:4-16 PMID: 29807069
  • Wei J, .et al. Inhibition of RHO Kinase by Fasudil Attenuates Ischemic Lung Injury After Cardiac Arrest in Rats, Shock, 2018, Dec;50(6):706-713 PMID: 29283979
  • Hofni A, .et al. Fasudil ameliorates endothelial dysfunction in streptozotocin-induced diabetic rats: a possible role of Rho kinase, Naunyn Schmiedebergs Arch Pharmacol, 2017, Aug;390(8):801-811 PMID: 28493050

Chemical Information

目录号 A10381
Mechanism of action Inhibitor
分子量 327.8
化学分子式 C14H17N3O2S.HCl
Solubility DMSO
纯度 >98%
储存方式 at -20°C 2 years
CAS No. 105628-07-7
Synonyms AT-877
SMILES code C1CNCCN(C1)S(=O)(=O)C2=CC=CC3=C2C=CN=C3.Cl
化学名称 1-(5-Isoquinolinesulfonyl)homopiperazine hydrochloride

生物活性

Description
Fasudil HCl is a cyclic nucleotide-dependent protein kinase inhibitor and Rho-associated kinase inhibitor (IC50 = 10.7 μM).
Targets
ROCK2 (Cell-free assay) PKA (Cell-free assay) PKG (Cell-free assay) PKC (Cell-free assay) MLCK (Cell-free assay)
330 nM(Ki)1.6 μM(Ki)1.6 μM(Ki)3.3 μM(Ki)36 μM(Ki)

溶解性

Solubility (25°C) * In vitro DMSO 5 mg/mL (15.25 mM)
Water 65 mg/mL (198.27 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo Saline 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 30.51 mL 152.53 mL 305.06mL
0.5 mM 6.1 mL 30.51 mL 61.01 mL
1 mM 3.05 mL 15.25 mL 30.51 mL
5 mM 0.61 mL 3.05 mL 6.1 mL

*The above data is based on the productmolecular weight 327.8 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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