FG-2216

Name: FG-2216
SKU: A15530

目录号: A15530

HIF-prolyl hydroxylase 抑制剂

FG-2216 Chemical Structure

CAS NO. 223387-75-5

FG-2216是一种有效的HIF-脯氨酰羟化酶抑制剂，对PDH2酶的IC50为3.9 uM；生物利用度并在体内诱导显着且可逆的Epo诱导。

库存：现货

规格	价格	数量
5 mg	￥ 550.00
10 mg	￥ 900.00
25 mg	￥ 1,800.00

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生物活性

FG-2216是一种有效的HIF-脯氨酰羟化酶抑制剂，对PDH2酶的IC50为3.9 uM；生物利用度并在体内诱导显着且可逆的Epo诱导。

靶点信息

PHD2
3.9 μM

溶解度 *

In vitro (25°C)	DMSO	48 mg/mL (171.02 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	2% DMSO+40% PEG 300+2% Twenn 80+ddH2O	28 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	35.63 mL	178.15 mL	356.3 mL
0.5 mM	7.13 mL	35.63 mL	71.26 mL
1 mM	3.56 mL	17.82 mL	35.63 mL
5 mM	0.71 mL	3.56 mL	7.13 mL

*The above data is based on the productmolecular weight 280.66. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

化学数据

目录号	A15530
作用机制	Inhibitor (抑制剂)
M. Wt	280.66
Formula	C12H9ClN2O4
Purity	>99%
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
CAS No.	223387-75-5
Synonyms	YM-311
SMILES	C1=CC=C2C(=C1)C(=C(N=C2Cl)C(=O)NCC(=O)O)O