FG-4592 (Roxadustat)

Name: FG-4592 (Roxadustat)
SKU: A11237
Price: 175 CNY
Rating: 5 (5 reviews)

目录号: A11237

HIF-PHs 抑制剂

5 篇发表文献

FG-4592 是一种新型的缺氧诱导因子脯氨酸羟化酶抑制剂，用于治疗慢性肾脏病（CKD）相关的贫血。

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Grouped product items
规格	价格	库存
5mg	¥175.00	现货
10mg	¥280.00	现货
25mg	¥420.00	现货
50mg	¥560.00	现货
100mg	¥770.00	现货
200mg	¥1,400.00	现货
500mg	¥1,960.00	现货
1g	¥3,780.00	现货
*10mM 1mL in DMSO**	¥280.00	现货
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重要通知：仅供研究使用。我们不向患者销售。

Data Sheet

SDS

顾客使用 Adooq 产品发表的高质量科研文献

Adooq用户使用FG-4592 (Roxadustat)发表的5篇文献

Weilin Song, .et al. , Biomedicines, 2022, Dec 23;11(1):37 PMID: 36672545

Singh C, .et al. , JCI Insight, 2019, Jul 25;4(14) PMID: 31341109

Hideaki Nakamura, .et al. , PLoS One, 2018, 13(2): e0192136 PMID: 29466367

Singh C, .et al. , Invest Ophthalmol Vis Sci, 2018, Jul 2;59(8):3440-3448 PMID: 30025089

George Hoppe, .et al. , Proc Natl Acad Sci U S A, 2016, May 3; 113(18): E2516-E2525 PMID: 27091985

生物活性

Discription

FG-4592 is a novel hypoxia inducible factor prolyl hydroxylase inhibitor, in CKD anemia.

Targets

Target	Value

产品信息

目录号	A11237
分子式	C19H16N2O5
分子量	352.3
CAS号	808118-40-3
SMILES	CC1=NC(=C(C2=C1C=C(C=C2)OC3=CC=CC=C3)O)C(=O)NCC(=O)O
其他名称	FG4592, ASP1517
储存条件	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

溶解性数据

In vitro (25°C)	DMSO	62 mg/mL (175.96 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	5% DMSO+40% PEG 300+5% Tween 80+50% ddH2O	9 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	28.38 mL	141.92 mL	283.85 mL
0.5 mM	5.68 mL	28.38 mL	56.77 mL
1 mM	2.84 mL	14.19 mL	28.38 mL
5 mM	0.57 mL	2.84 mL	5.68 mL

Useful Calculator

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Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

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* Please check COA/MSDS for correct molecular weight.

Calculate the dilution required to prepare a stock solution.
This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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