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Fidarestat (SNK 860) is an inhibitor of aldose reductase, with IC50s of 26 nM, 33 μM, and 1.8 μM for aldose reductase, AKR1B10 and V301L AKR1B10, respectively; Fidarestat (SNK 860) has the potential to treat diabetic disease.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 35.81 mL | 179.07 mL | 358.14 mL |
| 0.5 mM | 7.16 mL | 35.81 mL | 71.63 mL |
| 1 mM | 3.58 mL | 17.91 mL | 35.81 mL |
| 5 mM | 0.72 mL | 3.58 mL | 7.16 mL |
*The above data is based on the productmolecular weight 279.22. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A11790 |
|---|---|
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 279.22 |
| Formula | C12H10FN3O4 |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 136087-85-9 |
| Synonyms | SNK 860, SNK-860 |
| SMILES | O=C1NC(N[C@@]12C3=C(C=CC(F)=C3)O[C@H](C(N)=O)C2)=O |
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