Filgotinib

目录号: A14232

JAK 抑制剂

Filgotinib

Filgotinib Chemical Structure

CAS NO. 1206161-97-8

Filgotinib是一种选择性的JAK1抑制剂,对于JAK1,JAK2,JAK3和TYK2的IC50分别为10 nM,28 nM,810 nM和116 nM。

库存: 现货

规格 价格 数量
10 mg
¥ 1,100.00
25 mg
¥ 1,800.00
50 mg
¥ 2,800.00
10mM * 1mL in DMSO
¥ 750.00
Warning 产品仅用于科学研究,不针对患者销售,望谅解.

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Filgotinib是一种选择性的JAK1抑制剂,对于JAK1,JAK2,JAK3和TYK2的IC50分别为10 nM,28 nM,810 nM和116 nM。
靶点信息
JAK1 JAK2 TYK2 JAK3
10 nM28 nM116 nM810 nM
In vitro DMSO 85 mg/mL (199.76 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 23.5 mL 117.51 mL 235.02 mL
0.5 mM 4.7 mL 23.5 mL 47 mL
1 mM 2.35 mL 11.75 mL 23.5 mL
5 mM 0.47 mL 2.35 mL 4.7 mL

*The above data is based on the productmolecular weight 425.5. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

目录号 A14232
作用机制 Inhibitor (抑制剂)
M. Wt 425.5
Formula C21H23N5O3S
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 1206161-97-8
Synonyms GLPG0634
SMILES C1CC1C(=O)NC2=NN3C(=N2)C=CC=C3C4=CC=C(C=C4)CN5CCS(=O)(=O)CC5

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