Fimasartan
目录号: A17477
non-peptide angiotensin II receptor 拮抗剂
Fimasartan 是一种非肽类血管紧张素II受体拮抗剂（ARB），用于治疗高血压和心力衰竭。通过口服给药，fimasartan 阻断血管紧张素II受体类型1（AT1受体），减少血管紧张素II的促高血压作用，如系统性血管收缩和肾脏的水分保留。
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生物活性
| Discription | Fimasartan is a non-peptide angiotensin II receptor antagonist (ARB) used for the treatment of hypertension and heart failure. Through oral administration, fimasartan blocks angiotensin II receptor type 1 (AT1 receptors), reducing pro-hypertensive actions of angiotensin II, such as systemic vasoconstriction and water retention by the kidneys. | ||
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产品信息
| 目录号 | A17477 |
|---|---|
| 分子式 | C27H31N7OS |
| 分子量 | 501.65 |
| CAS号 | 247257-48-3 |
| SMILES | S=C(N(C)C)CC1=C(C)N=C(CCCC)N(CC2=CC=C(C3=CC=CC=C3C4=NN=NN4)C=C2)C1=O |
| 其他名称 | BR-A657; BR A657; BRA657; BRA 657; Fimasartan. brand name: Kanarb. |
| 储存条件 | Store lyophilized at -20ºC, keep desiccated. |
溶解性数据
| In vitro | DMSO | 97 mg/mL (193.36 mM) | |
| Ethanol | 23 mg/mL (45.85 mM) | ||
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* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
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Preparing Stock Solutions
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 19.93 mL | 99.67 mL | 199.34 mL |
| 0.5 mM | 3.99 mL | 19.93 mL | 39.87 mL |
| 1 mM | 1.99 mL | 9.97 mL | 19.93 mL |
| 5 mM | 0.4 mL | 1.99 mL | 3.99 mL |
Useful Calculator
Calculate the dilution required to prepare a stock solution. This equation is commonly abbreviated as: C1V1 = C2V2
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