FMK

Name: FMK
SKU: A11423
Price: 420 CNY
Rating: 5 (1 reviews)

目录号: A11423

RSK 抑制剂

1 篇发表文献

FMK 是一种强效、高度特异性且不可逆的 p90 核糖体蛋白 S6 激酶 RSK1 和 RSK2 抑制剂；FMK 结合在 CTKD ATP 结合位点，并抑制 RSK 在 Ser386 的自磷酸化。FMK 在表达人类 FGFR3、t(4;14)阳性的多发性骨髓瘤细胞中诱导显著的凋亡。

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Grouped product items
规格	价格	库存
1mg	¥420.00	现货
2mg	¥630.00	现货
5mg	¥1,190.00	现货
10mg	¥2,170.00	现货
25mg	¥3,710.00	现货
50mg	¥5,390.00	现货
100mg	¥7,595.00	现货
500mg	¥15,155.00	现货
*10mM 1mL in DMSO**	¥1,330.00	现货
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Data Sheet

SDS

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Adooq用户使用FMK发表的1篇文献

Huang-Ming Chang, .et al. , Cell Death Dis, 2021, Apr 17;12(5):409 PMID: 33866326

生物活性

Discription

FMK is potent, highly specific and irreversible inhibitor of p90 ribosomal protein S6 kinase RSK1 and RSK2; Fmk binds in the CTKD ATP-binding site and inhibits RSK autophosphorylation at Ser386. Fmk induces significant apoptosis in human FGFR3-expressing, t(4;14)-positive multiple myeloma cells.

Cell Research

Cell Line	Type	Value	Description	References

产品信息

目录号	A11423
分子式	C18H19FN4O2
分子量	342.37
CAS号	821794-92-7
SMILES	CC1=CC=C(C=C1)C2=C(N(C3=C2C(=NC=N3)N)CCCO)C(=O)CF
储存条件	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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