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FMK

RSK 抑制剂

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产品目录号: A11423

库存状态:中国现货中国现货

产品名 目录号 价格 数量
FMK 5mg A11423-5
¥ 1,800.00
FMK 10mg A11423-10
¥ 3,200.00
FMK 25mg A11423-25
¥ 6,400.00
FMK 50mg A11423-50
¥ 11,000.00

产品仅用于研究,不针对患者销售,望谅解.

产品简介

FMK is potent, highly specific and irreversible inhibitor of p90 ribosomal protein S6 kinase RSK1 and RSK2; Fmk binds in the CTKD ATP-binding site and inhibits RSK autophosphorylation at Ser386. Fmk induces significant apoptosis in human FGFR3-expressing, t(4;14)-positive multiple myeloma cells.

FMK

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Chemical Information

目录号 A11423
Mechanism of action Inhibitor
分子量 342.37
化学分子式 C18H19FN4O2
Solubility DMSO
纯度 >98%
储存方式 at -20°C 2 years
CAS No. 821794-92-7
Synonyms N/A
SMILES code CC1=CC=C(C=C1)C2=C(N(C3=C2C(=NC=N3)N)CCCO)C(=O)CF
化学名称 1-[4-Amino-7-(3-hydroxypropyl)-5-(4-methylphenyl)-7H-pyrrolo[2,3-d]pyrimidin-6-yl]-2-fluoroethanone

生物活性

Description
FMK is potent, highly specific and irreversible inhibitor of p90 ribosomal protein S6 kinase RSK1 and RSK2; Fmk binds in the CTKD ATP-binding site and inhibits RSK autophosphorylation at Ser386. Fmk induces significant apoptosis in human FGFR3-expressing, t(4;14)-positive multiple myeloma cells.

制备储备液

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 29.21 mL 146.04 mL 292.08mL
0.5 mM 5.84 mL 29.21 mL 58.42 mL
1 mM 2.92 mL 14.6 mL 29.21 mL
5 mM 0.58 mL 2.92 mL 5.84 mL

*The above data is based on the productmolecular weight 342.37. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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