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Foretinib (GSK1363089, XL880)


c-MET 抑制剂

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产品目录号: A10998


产品名 目录号 价格 数量
Foretinib 5mg A10998-5
¥ 400.00
Foretinib 25mg A10998-25
¥ 1,200.00
Foretinib 50mg A10998-50
¥ 2,200.00
Foretinib 100mg A10998-100
¥ 3,600.00
Foretinib 10mM * 1mL in DMSO A10998-10mM-D
¥ 700.00



Foretinib (GSK1363089), a multikinase inhibitor of c-Met and VEGFR-2, blocks proliferation, induces Anoikis, and impairs ovarian cancer metastasis.

Foretinib (GSK1363089, XL880)




顾客使用 Adooq 产品发表的高质量科研文献
Adooq 顾客使用 Foretinib (GSK1363089, XL880) 发表的文献 (3)
  • Hayato Ogura, .et al. TKI-addicted ROS1-rearranged cells are destined to survival or death by the intensity of ROS1 kinase activity, Sci Rep, 2017, 7: 5519 PMID: 28717217
  • Fuse MJ, .et al. Mechanisms of Resistance to NTRK Inhibitors and Therapeutic Strategies in NTRK1-Rearranged Cancers, Mol Cancer Ther, 2017, Oct;16(10):2130-2143 PMID: 28751539
  • Ryohei Katayama, .et al. Cabozantinib overcomes crizotinib resistance in ROS1 fusion positive cancer, Clin Cancer Res. , 2015, Jan 1; 21(1): 166每174. PMID: 25351743

Chemical Information

目录号 A10998
Mechanism of action Inhibitor
分子量 632.7
化学分子式 C34H34F2N4O6
Solubility DMSO
纯度 >98%
储存方式 at -20°C 2 years
CAS No. 849217-64-7
Synonyms GSK089, EXEL-2880
化学名称 N1’-[3-fluoro-4-[[6-methoxy-7-(3-morpholinopropoxy)-4-quinolyl]oxy]phenyl]-N1-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide


Foretinib (GSK1363089), a multikinase inhibitor of c-Met and VEGFR-2, blocks proliferation, induces Anoikis, and impairs ovarian cancer metastasis.
Target Value
MetIC50: 0.4nM
KDRIC50: 0.86nM
Tie-2IC50: 1.1nM
VEGFR3/FLT4IC50: 2.8nM
RONIC50: 3nM
FLT3IC50: 3.6nM
PDGFRαIC50: 3.6nM
KitIC50: 6.7nM
VEGFR1/FLT1IC50: 6.8nM
PDGFRβIC50: 9.6nM
FGFR1IC50: 660nM
EGFRIC50: 2.99μM


Solubility (25°C) * In vitro DMSO 127 mg/mL (200.74 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 30% propylene glycol, 5% Tween 80, 65% D5W 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.


Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 15.81 mL 79.03 mL 158.05mL
0.5 mM 3.16 mL 15.81 mL 31.61 mL
1 mM 1.58 mL 7.9 mL 15.81 mL
5 mM 0.32 mL 1.58 mL 3.16 mL

*The above data is based on the productmolecular weight 632.7. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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