Forimtamig (RG-6324) is a bispecific antibody designed for T-cell engagement, targeting GPRC5D and CD3. This molecule adopts a 2+1 configuration, incorporating two high-affinity binding sites for GPRC5D and a single site for CD3. It is engineered with a P329G LALA mutation in the Fc domain, which reduces binding to Fc?? receptors and C1q without affecting its interaction with the neonatal Fc receptor. The recommended isotype control for Forimtamig is Human IgG1 kappa. This antibody is pivotal in research focused on modulating immune responses, particularly in the context of cancer immunotherapy.
Forimtamig (RG-6324) is a bispecific antibody designed for T-cell engagement, targeting GPRC5D and CD3. This molecule adopts a 2+1 configuration, incorporating two high-affinity binding sites for GPRC5D and a single site for CD3. It is engineered with a P329G LALA mutation in the Fc domain, which reduces binding to Fc?? receptors and C1q without affecting its interaction with the neonatal Fc receptor. The recommended isotype control for Forimtamig is Human IgG1 kappa. This antibody is pivotal in research focused on modulating immune responses, particularly in the context of cancer immunotherapy.
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