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FR 167653 free base, an orally active and selective p38 MAPK inhibitor, is a potent suppressor of TNF-α and IL-1β production via specific inhibition of p38 MAPK activity.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 23.4 mL | 116.98 mL | 233.96 mL |
| 0.5 mM | 4.68 mL | 23.4 mL | 46.79 mL |
| 1 mM | 2.34 mL | 11.7 mL | 23.4 mL |
| 5 mM | 0.47 mL | 2.34 mL | 4.68 mL |
*The above data is based on the productmolecular weight 427.43. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A21110 |
|---|---|
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 427.43 |
| Formula | C24H18FN5O2 |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 158876-65-4 |
| Synonyms | FR167653, FR-167653 |
| SMILES | O=C(N1NC2=C(C3=CC=NC=C3)C(C4=CC=C(F)C=C4)=NN2CC1)C(C5=CC=CC=C5)=O |
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