Fresolimumab (GC1008) is a human monoclonal antibody designed to target and neutralize all active mammalian subtypes of Transforming Growth Factor-beta (TGF-??). It exhibits a high binding affinity to TGF-??2, with a dissociation constant (Kd) of 1.8 nM, indicating robust interaction with this cytokine. When conjugated with the radiolabel 89Zr, Fresolimumab serves as a valuable tool for Positron Emission Tomography (PET) analysis, facilitating the study of TGF-?? expression, antibody biodistribution, and organ-specific uptake. This antibody is extensively applicable in research focused on cancer, fibrosis, osteogenesis imperfecta, and kidney disease, providing insights into the pathophysiological roles of TGF-?? in these conditions.
Fresolimumab (GC1008) is a human monoclonal antibody designed to target and neutralize all active mammalian subtypes of Transforming Growth Factor-beta (TGF-??). It exhibits a high binding affinity to TGF-??2, with a dissociation constant (Kd) of 1.8 nM, indicating robust interaction with this cytokine. When conjugated with the radiolabel 89Zr, Fresolimumab serves as a valuable tool for Positron Emission Tomography (PET) analysis, facilitating the study of TGF-?? expression, antibody biodistribution, and organ-specific uptake. This antibody is extensively applicable in research focused on cancer, fibrosis, osteogenesis imperfecta, and kidney disease, providing insights into the pathophysiological roles of TGF-?? in these conditions.
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