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FTI 277

目录号: A12368
FTase 抑制剂
FTI 276 是一种抑制剂,能够抑制芳基转移酶(FTase)(IC50 = 0.5 nM)。在整个细胞中抑制 H-Ras 和 K-Ras 的处理(IC50 值分别为 0.1 和 10 μM),并且破坏了 H-Ras 特异性激活 MAPK 的常态。在人类恶性胶质瘤细胞和许多其他肿瘤细胞系中产生显著的抗增殖效果。
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规格 价格 库存 数量
5mg
¥595.00
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10mg
¥1,085.00
现货
25mg
¥2,065.00
现货
50mg
¥3,465.00
现货
100mg
¥5,320.00
现货
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重要通知:仅供研究使用。我们不向患者销售。

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生物活性
Discription FTI 276 is an inhibitor that inhibits farnesyltransferase (FTase) (IC50 = 0.5 nM). Inhibits H-Ras and K-Ras processing in whole cells (IC50 values are 0.1 and 10 μM respectively) and disrupts constitutive H-Ras-specific actvation of MAPK. Causes significant antiproliferative effects in human malignant glioma cells and many other tumor cell lines.
产品信息
目录号 A12368
分子式 C22H29N3O3S2.C2HF3O2
分子量 561.64
CAS号 170006-73-2, 1217447-06-7
SMILES COC(=O)[C@H](CCSC)NC(=O)C1=C(C=C(C=C1)NC[C@H](CS)N)C2=CC=CC=C2.C(=O)(C(F)(F)F)O
其他名称 FTI-277,FTI277, FTI-277 trifluoroacetate
储存条件

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:

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Please check COA/MSDS for correct molecular weight.

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This equation is commonly abbreviated as: C1V1 = C2V2

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