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FTI 277

FTase 抑制剂

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产品目录号: A12368

库存状态:中国现货中国现货

产品名 目录号 价格 数量
FTI 277 5mg A12368-5
¥ 900.00
FTI 277 10mg A12368-10
¥ 1,600.00
FTI 277 25mg A12368-25
¥ 3,000.00
FTI 277 50mg A12368-50
¥ 5,000.00

产品仅用于研究,不针对患者销售,望谅解.

产品简介

FTI 276 is an inhibitor that inhibits farnesyltransferase (FTase) (IC50 = 0.5 nM). Inhibits H-Ras and K-Ras processing in whole cells (IC50 values are 0.1 and 10 μM respectively) and disrupts constitutive H-Ras-specific actvation of MAPK. Causes significant antiproliferative effects in human malignant glioma cells and many other tumor cell lines.

FTI 277

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Chemical Information

目录号 A12368
Mechanism of action Inhibitor
分子量 561.64
化学分子式 C22H29N3O3S2.C2HF3O2
Solubility DMSO
纯度 >98%
储存方式 at -20°C 2 years
CAS No. 170006-73-2
Synonyms FTI-277,FTI277
SMILES code CSCC[C@H](NC(=O)C1CCC(NC[C@@H](N)CS)CC1C1CCCCC1)C(=O)OC.OC(=O)C(F)(F)F
化学名称 N-[4-[2(R)-Amino-3-mercaptopropyl]a?mino-2-phenylbenzoyl]methionine methyl ester trifluoroacetate salt

生物活性

Description
FTI 276 is an inhibitor that inhibits farnesyltransferase (FTase) (IC50 = 0.5 nM). Inhibits H-Ras and K-Ras processing in whole cells (IC50 values are 0.1 and 10 μM respectively) and disrupts constitutive H-Ras-specific actvation of MAPK. Causes significant antiproliferative effects in human malignant glioma cells and many other tumor cell lines.

制备储备液

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 17.8 mL 89.02 mL 178.05mL
0.5 mM 3.56 mL 17.8 mL 35.61 mL
1 mM 1.78 mL 8.9 mL 17.8 mL
5 mM 0.36 mL 1.78 mL 3.56 mL

*The above data is based on the productmolecular weight 561.64. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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