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FLT3 抑制剂

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产品目录号: A14214


产品名 目录号 价格 数量
G-749 5mg A14214-5
¥ 1,200.00
G-749 10mg A14214-10
¥ 2,100.00
G-749 25mg A14214-25
¥ 4,700.00
G-749 10mM * 1mL in DMSO A14214-10mM-D
¥ 1,380.00



G-749 is a novel and potent FLT3 inhibitor with IC50 of 0.4 nM, 0.6 nM and 1 nM for FLT3 (WT), FLT3 (D835Y).





顾客使用 Adooq 产品发表的高质量科研文献

Chemical Information

目录号 A14214
Mechanism of action Inhibitor
分子量 521.41
化学分子式 C25H25BrN6O2
Solubility DMSO
纯度 >98%
储存方式 at -20°C 2 years
CAS No. 1457983-28-6
Synonyms G749
化学名称 8-bromo-2-[(1-methyl-4-piperidinyl)amino]-4-[(4-phenoxyphenyl)amino]-pyrido[4,3-d]pyrimidin-5(6H)-one


G-749 is a novel and potent FLT3 inhibitor with IC50 of 0.4 nM, 0.6 nM and 1 nM for FLT3 (WT), FLT3 (D835Y).
Target Value
FLT3IC50: 0.4nM
FLT3(D835Y)IC50: 0.6nM
MerIC50: 1nM
AuroraBIC50: 6nM
RETIC50: 9nM
FmsIC50: 19nM
AxlIC50: 20nM
AuroraCIC50: 24nM
FGFR1IC50: 25nM
FGFR3IC50: 30nM
c-KitIC50: 142nM
IGF-1RIC50: >300nM
PDGFRαIC50: >300nM
PDGFRβIC50: >300nM


Solubility (25°C)* In vitro DMSO 24 mg/mL heating (46.02 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.


Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 19.18 mL 95.89 mL 191.79mL
0.5 mM 3.84 mL 19.18 mL 38.36 mL
1 mM 1.92 mL 9.59 mL 19.18 mL
5 mM 0.38 mL 1.92 mL 3.84 mL

*The above data is based on the productmolecular weight 521.41. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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