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Gambogenic acid is an active ingredient in gamboge, with anticancer activity. Gambogenic acid acts as an effective inhibitor of EZH2, specifically and covalently binds to Cys668 within the EZH2-SET domain, and induces EZH2 ubiquitination.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 15.85 mL | 79.27 mL | 158.54 mL |
| 0.5 mM | 3.17 mL | 15.85 mL | 31.71 mL |
| 1 mM | 1.59 mL | 7.93 mL | 15.85 mL |
| 5 mM | 0.32 mL | 1.59 mL | 3.17 mL |
*The above data is based on the productmolecular weight 630.77. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A22383 |
|---|---|
| M. Wt | 630.77 |
| Formula | C38H46O8 |
| Solubility | DMSO |
| Purity | >98% |
| Storage | at -20°C 2 years |
| CAS No. | 173932-75-7 |
| SMILES | O=C(O)/C(C)=C\C[C@@]1(C2=O)OC(C)(C)[C@]([C@]31OC4=C5C(O)=C(C/C=C(C)/CC/C=C(C)\C)C(O)=C4C/C=C(C)\C)([H])C[C@@]2([H])C=C3C5=O |
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