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Gambogic acid

促销

Bcl-2 抑制剂

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产品目录号: A11988

库存状态:中国现货中国现货

产品名 目录号 价格 数量
Gambogic acid 10mg A11988-10
¥ 700.00
Gambogic acid 25mg A11988-25
¥ 1,800.00
Gambogic acid 50mg A11988-50
¥ 3,000.00
Gambogic acid 100mg A11988-100
¥ 5,000.00

产品仅用于研究,不针对患者销售,望谅解.

产品简介

Gambogic acid is a natural product isolated from the Garcinia hanburyi tree. Gambogic Acid activates caspases with EC50 of 0.78-1.64 μM and competitively inhibits Bcl-XL, Bcl-2, Bcl-W, Bcl-B, Bfl-1 and Mcl-1 with IC50 of 1.47, 1.21, 2.02, 0.66, 1.06 and 0.79 μM, respectively.

Gambogic acid

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Chemical Information

目录号 A11988
Mechanism of action
分子量 628.75
化学分子式 C38H44O8
Solubility DMSO
纯度 >98%
储存方式 at -20°C 2 years
CAS No. 2752-65-0
Synonyms N/A
SMILES code CC(=CCC[C@@]1(C=CC2=C(O1)C(=C3C(=C2O)C(=O)C4=C[C@@H]5C[C@@H]6[C@@]4(O3)[C@](C5=O)(OC6(C)C)C/C=C(/C)\C(=O)O)CC=C(C)C)C)C
化学名称 (2Z)-2-Methyl-4-[(1R,3aS,5S,11R,14a?S)-3a,4,5,7-tetrahydro-8-hydroxy-3,3,11-trimethyl-?13-(3-methyl-2-butenyl)-11-(4-methyl-3-pentenyl)-7?,15-dioxo-1,5-methano-1H,3H,11H-furo[3,4-g]pyrano[?3,2-b]xanthen-1-yl]-2-butenoic acid

生物活性

Description
Gambogic acid is a natural product isolated from the Garcinia hanburyi tree. Gambogic Acid activates caspases with EC50 of 0.78-1.64 μM and competitively inhibits Bcl-XL, Bcl-2, Bcl-W, Bcl-B, Bfl-1 and Mcl-1 with IC50 of 1.47, 1.21, 2.02, 0.66, 1.06 and 0.79 μM, respectively.
Targets
Target Value
Bcl-wIC50: 0.02μM
Bcl-BIC50: 0.66μM
Mcl-1IC50: 0.79μM
Bfl-1IC50: 1.06μM
Bcl-2IC50: 1.21μM
Bcl-xLIC50: 1.47μM
CaspaseEC50<1.64μM

制备储备液

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 15.9 mL 79.52 mL 159.05mL
0.5 mM 3.18 mL 15.9 mL 31.81 mL
1 mM 1.59 mL 7.95 mL 15.9 mL
5 mM 0.32 mL 1.59 mL 3.18 mL

*The above data is based on the productmolecular weight 628.75. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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