Ganitumab (AMG 479) is a recombinant human monoclonal antibody specifically targeting the human type 1 insulin-like growth factor receptor (IGF1R). This antibody exhibits high specificity and affinity for murine IGF1R, with a dissociation constant (K_D) of 0.22 nM, effectively inhibiting the interaction between murine IGF1R and its ligands, IGF1 and IGF2. Ganitumab is primarily utilized in oncological research to study the role of the IGF1R pathway in cancer progression and potential therapeutic interventions.
Ganitumab (AMG 479) is a recombinant human monoclonal antibody specifically targeting the human type 1 insulin-like growth factor receptor (IGF1R). This antibody exhibits high specificity and affinity for murine IGF1R, with a dissociation constant (K_D) of 0.22 nM, effectively inhibiting the interaction between murine IGF1R and its ligands, IGF1 and IGF2. Ganitumab is primarily utilized in oncological research to study the role of the IGF1R pathway in cancer progression and potential therapeutic interventions.
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