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GANT61

促销

GLI 拮抗剂

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产品目录号: A13252

库存状态:中国现货中国现货

产品名 目录号 价格 数量
GANT61 10mg A13252-10
¥ 750.00
GANT61 25mg A13252-25
¥ 1,500.00
GANT61 50mg A13252-50
¥ 2,800.00
GANT61 100mg A13252-100
¥ 4,800.00
GANT61 10mM * 1mL in DMSO A13252-10mM-D
¥ 550.00

产品仅用于研究,不针对患者销售,望谅解.

产品简介

GANT61 is an inhibitor for GLI1 as well as GLI2-induced transcription, inhibits hedgehog with IC50 of 5 μM, displays selectivity over other pathways, such as TNF and glucocorticoid receptor gene transactivation.

GANT61

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顾客使用 Adooq 产品发表的高质量科研文献
Adooq 顾客使用 GANT61 发表的文献 (1)
  • Hui Liang, .et al. Targeting the PI3K/AKT pathway via GLI1 inhibition enhanced the drug sensitivity of acute myeloid leukemia cells, Sci Rep, 2017, 7: 40361 PMID: 28098170

Chemical Information

目录号 A13252
Mechanism of action Antagonist
分子量 429.61
化学分子式 C27H35N5
Solubility DMSO
纯度 >98%
储存方式 at -20°C 2 years
CAS No. 500579-04-4
Synonyms NSC136476, NSC-136476, GANT 61, GANT-61
SMILES code CN(C)C1=CC=CC=C1CN2CCCN(C2C3=CC=NC=C3)CC4=CC=CC=C4N(C)C
化学名称 2,2'-[[Dihydro-2-(4-pyridinyl)-1,3(2?H,4H)-pyrimidinediyl]bis(methylene)]bis[N,N-dimeth?ylbenzenamine

生物活性

Description
GANT61 is an inhibitor for GLI1 as well as GLI2-induced transcription, inhibits hedgehog with IC50 of 5 μM, displays selectivity over other pathways, such as TNF and glucocorticoid receptor gene transactivation.
Targets
GLI1 (HEK293T cells expressing GLI1)
5 μM

溶解性

Solubility (25°C) * In vitro DMSO 12 mg/mL (27.93 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 5% DMSO/95% Corn oil 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 23.28 mL 116.38 mL 232.77mL
0.5 mM 4.66 mL 23.28 mL 46.55 mL
1 mM 2.33 mL 11.64 mL 23.28 mL
5 mM 0.47 mL 2.33 mL 4.66 mL

*The above data is based on the productmolecular weight 429.61. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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