GDC-0349
目录号: A11443
mTOR 抑制剂
GDC-0349 是一种强效且选择性的 mTOR ATP竞争性抑制剂，其Ki值为3.8 nM，对PI3Kα及其他266种激酶具有790倍的抑制效果。
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生物活性
| Discription | GDC-0349 is a potent and selective ATP-competitive inhibitor of mTOR with Ki of 3.8 nM, 790-fold inhibitory effect against PI3Kα and other 266 kinases. | |||||
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| Cell Research |
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产品信息
| 目录号 | A11443 |
|---|---|
| 分子式 | C24H32N6O3 |
| 分子量 | 452.6 |
| CAS号 | 1207360-89-1 |
| SMILES | CCNC(=O)NC1=CC=C(C=C1)C2=NC3=C(CCN(C3)C4COC4)C(=N2)N5CCOC[C@@H]5C |
| 其他名称 | GDC 0349, RG7603 |
| 储存条件 | Store lyophilized at -20ºC, keep desiccated. |
溶解性数据
| In vitro | DMSO | 79 mg/mL (174.56 mM) | |
| Water | Insoluble | ||
| Ethanol | 5 mg/mL (11.04 mM) | ||
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* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
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Preparing Stock Solutions
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 22.09 mL | 110.47 mL | 220.95 mL |
| 0.5 mM | 4.42 mL | 22.09 mL | 44.19 mL |
| 1 mM | 2.21 mL | 11.05 mL | 22.09 mL |
| 5 mM | 0.44 mL | 2.21 mL | 4.42 mL |
Useful Calculator
Calculate the dilution required to prepare a stock solution. This equation is commonly abbreviated as: C1V1 = C2V2
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| 购买 1207360-89-1 | 1207360-89-1 供应商 | 1207360-89-1 花费 | 1207360-89-1 生产商 | 订购 1207360-89-1 | 1207360-89-1 代理商