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GDC-0449 (Vismodegib)

促销

Hedgehog 拮抗剂

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产品目录号: A10258

库存状态:中国现货中国现货

产品名 目录号 价格 数量
GDC-0449 25mg A10258-25
¥ 500.00
GDC-0449 50mg A10258-50
¥ 600.00
GDC-0449 200mg A10258-200
¥ 1,100.00
GDC-0449 (Vismodegib) 10mM * 1mL in DMSO A10258-10mM-D
¥ 500.00

产品仅用于研究,不针对患者销售,望谅解.

产品简介

GDC-0449 (Vismodegib) is a more potent novel and specific synthetic oral hedgehog pathway inhibitor with an IC50 of 3 nM.

GDC-0449 (Vismodegib)

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顾客使用 Adooq 产品发表的高质量科研文献
Adooq 顾客使用 GDC-0449 (Vismodegib) 发表的文献 (2)
  • Yi Yang, .et al. Tumidulin, a Lichen Secondary Metabolite, Decreases the Stemness Potential of Colorectal Cancer Cells, Molecules, 2018, Nov; 23(11): 2968 PMID: 30441806
  • Olesen UH, .et al. Topical delivery of vismodegib using ablative fractional laser and micro-emulsion formulation in vitro, Lasers Surg Med, 2018, Aug 28 PMID: 30152536

Chemical Information

目录号 A10258
Mechanism of action Antagonist
分子量 421.3
化学分子式 C19H14Cl2N2O3S
Solubility DMSO>84mg/mL Water<1mg/mL Ethanol>10mg/mL
纯度 >98%
储存方式 at -20°C 2 years
CAS No. 879085-55-9
Synonyms N/A
SMILES code CN1C=NC2=C1C=C(C(=C2F)NC3=C(C=C(C=C3)Br)Cl)C(=O)NOCCO
化学名称 2-chloro-N-[4-chloro-3-(pyridin-2-yl)phenyl]-4-(methylsulfonyl)benzamide

生物活性

Description
GDC-0449 (Vismodegib) is a more potent novel and specific synthetic oral hedgehog pathway inhibitor with an IC50 of 3 nM.

溶解性

Solubility (25°C) * In vitro DMSO 84 mg/mL (199.38 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 0.5% methylcellulose/0.2% Tween 80 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 23.74 mL 118.68 mL 237.36mL
0.5 mM 4.75 mL 23.74 mL 47.47 mL
1 mM 2.37 mL 11.87 mL 23.74 mL
5 mM 0.47 mL 2.37 mL 4.75 mL

*The above data is based on the productmolecular weight 421.3. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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