GDC-0449 (Vismodegib)

目录号: A10258

Hedgehog antagonist

GDC-0449 (Vismodegib)

GDC-0449 (Vismodegib) Chemical Structure

CAS NO. 879085-55-9

GDC-0449 (Vismodegib) is a more potent novel and specific synthetic oral hedgehog pathway inhibitor with an IC50 of 3 nM.

库存: 现货

规格 价格 数量
25 mg
¥ 500.00
50 mg
¥ 600.00
200 mg
¥ 1,100.00
10mM * 1mL in DMSO
¥ 500.00
Warning 产品仅用于科学研究,不针对患者销售,望谅解.

详情

GDC-0449 (Vismodegib) is a more potent novel and specific synthetic oral hedgehog pathway inhibitor with an IC50 of 3 nM.
In vitro (25°C) DMSO 84 mg/mL (199.38 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 0.5% methylcellulose/0.2% Tween 80 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 23.74 mL 118.68 mL 237.36 mL
0.5 mM 4.75 mL 23.74 mL 47.47 mL
1 mM 2.37 mL 11.87 mL 23.74 mL
5 mM 0.47 mL 2.37 mL 4.75 mL

*The above data is based on the productmolecular weight 421.3. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Technical Details

目录号 A10258
MECHANISM OF ACTION Antagonist
M. Wt 421.3
Formula C19H14Cl2N2O3S
Solubility DMSO>84mg/mL Water<1mg/mL Ethanol>10mg/mL
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 879085-55-9
Synonyms N/A
SMILES ClC1=C(C=C(NC(C2=CC=C(S(C)(=O)=O)C=C2Cl)=O)C=C1)C3=NC=CC=C3

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