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GDC-0623

MEK1 抑制剂

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产品目录号: A12974

库存状态:中国现货中国现货

产品名 目录号 价格 数量
GDC-0623 5mg A12974-5
¥ 1,400.00
GDC-0623 10mg A12974-10
¥ 2,500.00
GDC-0623 25mg A12974-25
¥ 5,500.00

产品仅用于研究,不针对患者销售,望谅解.

产品简介

GDC-0623 is a potent and ATP-uncompetitive MEK1 inhibitor with Ki of 0.13 nM. Phase 1.

GDC-0623

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Chemical Information

目录号 A12974
Mechanism of action Inhibitor
分子量 456.21
化学分子式 C16H14FIN4O3
Solubility DMSO
纯度 >98%
储存方式 at -20°C 2 years
CAS No. 1168091-68-6
Synonyms GDC0623, GDC 0632
SMILES code O=C(C1=C(NC2=CC=C(I)C=C2F)N3C(C=C1)=CN=C3)NOCCO
化学名称 5-((2-fluoro-4-iodophenyl)amino)-N-(2-hydroxyethoxy)imidazo[1,5-a]pyridine-6-carboxamide

生物活性

Description
GDC-0623 is a potent and ATP-uncompetitive MEK1 inhibitor with Ki of 0.13 nM. Phase 1.
Targets
MEK1
0.13 nM

制备储备液

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 21.92 mL 109.6 mL 219.2mL
0.5 mM 4.38 mL 21.92 mL 43.84 mL
1 mM 2.19 mL 10.96 mL 21.92 mL
5 mM 0.44 mL 2.19 mL 4.38 mL

*The above data is based on the productmolecular weight 456.21. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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