GDC-0623
目录号: A12974
MEK1 抑制剂
GDC-0623 是一种强效且与ATP非竞争性的 MEK1 抑制剂，Ki 值为 0.13 nM。目前处于第一阶段临床试验。
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生物活性
| Discription | GDC-0623 is a potent and ATP-uncompetitive MEK1 inhibitor with Ki of 0.13 nM. Phase 1. | |||||
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| Cell Research |
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产品信息
| 目录号 | A12974 |
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| 分子式 | C16H14FIN4O3 |
| 分子量 | 456.21 |
| CAS号 | 1168091-68-6 |
| SMILES | O=C(C1=C(NC2=CC=C(I)C=C2F)N3C(C=C1)=CN=C3)NOCCO |
| 其他名称 | GDC0623, GDC 0632 |
| 储存条件 | Store lyophilized at -20ºC, keep desiccated. |
溶解性数据
| In vitro (25°C) | DMSO | Warmed: 89 mg/mL (195.08 mM) | |
| Water | Insoluble | ||
| Ethanol | Warmed: 5 mg/mL (10.95 mM) | ||
| In vivo | 5% DMSO+45% PEG 300+ddH2O | 19 mg/mL | |
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* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
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Preparing Stock Solutions
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 21.92 mL | 109.6 mL | 219.2 mL |
| 0.5 mM | 4.38 mL | 21.92 mL | 43.84 mL |
| 1 mM | 2.19 mL | 10.96 mL | 21.92 mL |
| 5 mM | 0.44 mL | 2.19 mL | 4.38 mL |
Useful Calculator
Calculate the dilution required to prepare a stock solution. This equation is commonly abbreviated as: C1V1 = C2V2
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| 购买 1168091-68-6 | 1168091-68-6 供应商 | 1168091-68-6 花费 | 1168091-68-6 生产商 | 订购 1168091-68-6 | 1168091-68-6 代理商