|B-Raf (A375, Colo205 cells)|
|In vitro (25°C)||DMSO||67 mg/mL (200.37 mM)|
|Water||<1 mg/mL (<1 mM)|
|Ethanol||5 mg/mL (14.95 mM)|
|In vivo||0.5% methylcellulose/0.2% Tween 80||30 mg/mL|
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.1 mM||29.9 mL||149.52 mL||299.04 mL|
|0.5 mM||5.98 mL||29.9 mL||59.81 mL|
|1 mM||2.99 mL||14.95 mL||29.9 mL|
|5 mM||0.6 mL||2.99 mL||5.98 mL|
*The above data is based on the productmolecular weight 334.4 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|MECHANISM OF ACTION||Inhibitor|
|Storage||at -20°C 3 years Powder|
ZM 336372 is a potent ATP-competitive inhibitor of Raf-1 in vitro (IC50 = 70 nM) with the paradoxical effect of inducing >100-fold activatio…
CEP-32496 hydrochloride is a highly potent inhibitor of wild-type BRAF, V600E mutant BRAF and c-Raf with Kd values of 14 nM, 36 nM and 39 nM…
Diazepinomicin, also known as TLN-4601, is a small-molecule inhibitor of the RAS/RAF/MAPK signaling pathway with potential antineoplastic ac…
AZ628 is a RAF inhibitor with IC50 values: ca 30 nM for BRAF V600E and wild-type CRAF and 100 nM for wild-type BRAF.
MLN 2480 is an oral, selective pan-Raf kinase inhibitor in chinical trials.
ML 786 dihydrochloride is a potent Raf kinase inhibitor (IC50 values are 2.1, 2.5 and 4.2 nM for B-RafV600E, C-Raf and wild-type B-Raf respe…