GDC-0973 (Cobimetinib)

Name: GDC-0973 (Cobimetinib)
SKU: A11441
Price: 175 CNY
Rating: 5 (2 reviews)

目录号: A11441

MEK1 抑制剂

2 篇发表文献

Cobimetinib（GDC-0973，RG7420）是一种强效且高度选择性的 MEK1 抑制剂，其 IC50 为 4.2 nM，对 MEK1 的选择性超过 MEK2 的100倍以上，并且在针对100多种丝氨酸-苏氨酸和酪氨酸激酶的测试中未显示出显著抑制作用。

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Grouped product items
规格	价格	库存
1mg	¥175.00	现货
2mg	¥280.00	现货
5mg	¥490.00	现货
10mg	¥630.00	现货
25mg	¥1,225.00	现货
50mg	¥1,995.00	现货
100mg	¥3,290.00	现货
*10mM 1mL in DMSO**	¥595.00	现货
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重要通知：仅供研究使用。我们不向患者销售。

Data Sheet

SDS

顾客使用 Adooq 产品发表的高质量科研文献

Adooq用户使用GDC-0973 (Cobimetinib)发表的2篇文献

Yunping Hu, .et al. , Cancer Lett, 2022, Oct 28;547:215867 PMID: 35985510

Seidel D, .et al. , Biosens Bioelectron, 2019, Jan 1;123:185-194 PMID: 30201332

生物活性

Discription

Cobimetinib (GDC-0973, RG7420) is a potent and highly selective MEK1 inhibitor with IC50 of 4.2 nM, showing more than 100-fold selectively for MEK1 over MEK2 and showed no significant inhibition when tested against a panel of more than 100 of serine-threonine and tyrosine kinases.

Targets

Target	Value

产品信息

目录号	A11441
分子式	C21H21F3IN3O2
分子量	530.1
CAS号	934660-93-2
SMILES	C1CCN[C@@H](C1)C2(CN(C2)C(=O)C3=C(C(=C(C=C3)F)F)NC4=C(C=C(C=C4)I)F)O
其他名称	XL518, XL 518, XL-518, RG7420
储存条件	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

溶解性数据

In vitro (25°C)	DMSO	88 mg/mL (165.62 mM)
	Water	Insoluble
	Ethanol	Warmed: 41 mg/mL (77.17 mM)
In vivo	5% DMSO+30% PEG 300+5% Tween 80+ddH2O	4 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	18.86 mL	94.32 mL	188.64 mL
0.5 mM	3.77 mL	18.86 mL	37.73 mL
1 mM	1.89 mL	9.43 mL	18.86 mL
5 mM	0.38 mL	1.89 mL	3.77 mL

Useful Calculator

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Calculate the dilution required to prepare a stock solution.
This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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