GDC-0973 (Cobimetinib)

目录号: A11441

MEK1 inhibitor

GDC-0973 (Cobimetinib)

GDC-0973 (Cobimetinib) Chemical Structure

CAS NO. 934660-93-2

Cobimetinib (GDC-0973, RG7420) is a potent and highly selective MEK1 inhibitor with IC50 of 4.2 nM, showing more than 100-fold selectively for MEK1 over MEK2 and showed no significant inhibition when tested against a panel of more than 100 of serine-threonine and tyrosine kinases.

库存: 现货

规格 价格 数量
5 mg
¥ 1,200.00
10 mg
¥ 1,800.00
25 mg
¥ 3,500.00
Warning 产品仅用于科学研究,不针对患者销售,望谅解.

详情

Cobimetinib (GDC-0973, RG7420) is a potent and highly selective MEK1 inhibitor with IC50 of 4.2 nM, showing more than 100-fold selectively for MEK1 over MEK2 and showed no significant inhibition when tested against a panel of more than 100 of serine-threonine and tyrosine kinases.
Targets
MEK1
4.2 nM
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 18.86 mL 94.32 mL 188.64 mL
0.5 mM 3.77 mL 18.86 mL 37.73 mL
1 mM 1.89 mL 9.43 mL 18.86 mL
5 mM 0.38 mL 1.89 mL 3.77 mL

*The above data is based on the productmolecular weight 530.1 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

目录号 A11441
MECHANISM OF ACTION Inhibitor
M. Wt 530.1
Formula C21H21F3IN3O2
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 934660-93-2
Synonyms XL518, XL 518, XL-518, RG7420
SMILES C1CCN[C@@H](C1)C2(CN(C2)C(=O)C3=C(C(=C(C=C3)F)F)NC4=C(C=C(C=C4)I)F)O

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