GDC-0980 (Apitolisib, RG7422)

目录号: A11023

mTOR/PI3K Inhibitor

GDC-0980 (Apitolisib, RG7422) Chemical Structure

CAS NO. 1032754-93-0

GDC-0980 (RG7422) is a selective, potent, orally bioavailable inhibitor of Class I PI3 kinase and mTOR kinase (TORC1/2) with in vitro IC50 of 5, 27, 7 and 14 nM for p110 α, β, δ and γ isoforms, respectively.

库存: 现货

规格 价格 数量
5 mg
¥ 600.00
10 mg
¥ 1,000.00
50 mg
¥ 2,600.00
100 mg
¥ 4,400.00
10mM * 1mL in DMSO
¥ 750.00
Warning 产品仅用于科学研究,不针对患者销售,望谅解.

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GDC-0980 (RG7422) is a selective, potent, orally bioavailable inhibitor of Class I PI3 kinase and mTOR kinase (TORC1/2) with in vitro IC50 of 5, 27, 7 and 14 nM for p110 α, β, δ and γ isoforms, respectively.
Targets
p110α (Cell-free assay) p110δ (Cell-free assay) p110γ (Cell-free assay) mTOR (Cell-free assay) p110β (Cell-free assay)
5 nM7 nM14 nM17 nM(Ki app)27 nM
In vitro (25°C) DMSO 20 mg/mL (40.11 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 0.5% methylcellulose/0.2% Tween 80 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 20.06 mL 100.28 mL 200.56 mL
0.5 mM 4.01 mL 20.06 mL 40.11 mL
1 mM 2.01 mL 10.03 mL 20.06 mL
5 mM 0.4 mL 2.01 mL 4.01 mL

*The above data is based on the productmolecular weight 498.6 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

目录号 A11023
MECHANISM OF ACTION Inhibitor
M. Wt 498.6
Formula C23H30N8O3S
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 1032754-93-0
Synonyms GDC0980
SMILES CC1=C(SC2=C1N=C(N=C2N3CCOCC3)C4=CN=C(N=C4)N)CN5CCN(CC5)C(=O)[C@H](C)O

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