GDC0994

目录号: A13420

ERK1/2 inhibitor

GDC0994

GDC0994 Chemical Structure

CAS NO. 1453848-26-4

GDC-0994 is a potent and selective Erk1/2 inhibitor. GDC-0994 inhibits both ERK phosphorylation and activation of ERK-mediated signal transduction pathways.

库存: 现货

规格 价格 数量
5 mg
¥ 800.00
10 mg
¥ 1,000.00
25 mg
¥ 1,900.00
10mM * 1mL in DMSO
¥ 850.00
Warning 产品仅用于科学研究,不针对患者销售,望谅解.

详情

GDC-0994 is a potent and selective Erk1/2 inhibitor. GDC-0994 inhibits both ERK phosphorylation and activation of ERK-mediated signal transduction pathways.
Targets
ERK2 ERK1
0.3 nM1.1 nM
In vitro DMSO 88 mg/mL (200.06 mM)
Water <1 mg/mL (<1 mM)
Ethanol 88 mg/mL (200.06 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 22.68 mL 113.41 mL 226.82 mL
0.5 mM 4.54 mL 22.68 mL 45.36 mL
1 mM 2.27 mL 11.34 mL 22.68 mL
5 mM 0.45 mL 2.27 mL 4.54 mL

*The above data is based on the productmolecular weight 440.87. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

目录号 A13420
MECHANISM OF ACTION Inhibitor
M. Wt 440.87
Formula C21H18ClFN6O2
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 1453848-26-4
Synonyms GDC-0994
SMILES CN1C(=CC=N1)NC2=NC=CC(=N2)C3=CC(=O)N(C=C3)[C@H](CO)C4=CC(=C(C=C4)Cl)F

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