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Gefapixant

Gefapixant

Name: Gefapixant
SKU: A19254

目录号: A19254

P2X3R antagonist

Gefapixant Chemical Structure

CAS NO. 1015787-98-0

Gefapixant is an orally active P2X3 receptor (P2X3R) antagonist with IC50s of ~30 nM versus recombinant hP2X3 homotrimers and 100-250 nM at hP2X2/3 heterotrimeric receptors.

库存：现货

规格	价格	数量
5 mg	￥ 990.00
10 mg	￥ 1,710.00
50 mg	￥ 5,060.00
100 mg	￥ 10,120.00

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生物活性

Gefapixant is an orally active P2X3 receptor (P2X3R) antagonist with IC50s of ~30 nM versus recombinant hP2X3 homotrimers and 100-250 nM at hP2X2/3 heterotrimeric receptors.

溶解度 *

In vitro	DMSO	65 mg/mL (183.92 mM)
	Water	Insoluble
	Ethanol	Insoluble
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	28.3 mL	141.48 mL	282.97 mL
0.5 mM	5.66 mL	28.3 mL	56.59 mL
1 mM	2.83 mL	14.15 mL	28.3 mL
5 mM	0.57 mL	2.83 mL	5.66 mL

*The above data is based on the productmolecular weight 353.4. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

化学数据

目录号	A19254
M. Wt	353.4
Formula	C14H19N5O4S
Purity	>99%
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
CAS No.	1015787-98-0
Synonyms	AF219, AF 219, AF-219; MK-7264, MK7264, MK 7264
SMILES	O=S(C1=CC(OC2=CN=C(N)N=C2N)=C(C(C)C)C=C1OC)(N)=O