Gevokizumab is a potent monoclonal antibody that targets interleukin-1 beta (IL-1??), employing an allosteric mechanism to modulate IL-1?? signaling negatively. This antibody selectively reduces the binding affinity of IL-1?? to its signaling receptor, interleukin-1 receptor type I (IL-1RI), rather than affecting the interaction with the IL-1 counter-regulatory decoy receptor, interleukin-1 receptor type II (IL-1RII). This specificity in modulation facilitates the detailed study of IL-1?? signaling pathways and their physiological and pathological roles. Gevokizumab is instrumental in research focused on inflammation and immune response, offering potential therapeutic insights into diseases mediated by IL-1??.
Gevokizumab is a potent monoclonal antibody that targets interleukin-1 beta (IL-1??), employing an allosteric mechanism to modulate IL-1?? signaling negatively. This antibody selectively reduces the binding affinity of IL-1?? to its signaling receptor, interleukin-1 receptor type I (IL-1RI), rather than affecting the interaction with the IL-1 counter-regulatory decoy receptor, interleukin-1 receptor type II (IL-1RII). This specificity in modulation facilitates the detailed study of IL-1?? signaling pathways and their physiological and pathological roles. Gevokizumab is instrumental in research focused on inflammation and immune response, offering potential therapeutic insights into diseases mediated by IL-1??.
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