GF 109203X

目录号: A13197

PKC inhibitor

GF 109203X

GF 109203X Chemical Structure

CAS NO. 133052-90-1

GF 109203X is a potent and selective inhibitor of protein kinase C, selective for the α and β1 isoforms (IC50 values are 0.0084, 0.0180, 0.210, 0.132, and 5.8 μM for α, β1, δ, ε and ζ isoforms respectively). Selective over MLCK, PKG and PKA (IC50 values are 0.6, 4.6, and 33 μM respectively). Potent antagonist at the 5-HT3 receptor (Ki = 29.5 nM).

库存: 现货

规格 价格 数量
10 mg
¥ 1,200.00
25 mg
¥ 2,400.00
50 mg
¥ 4,500.00
100 mg
¥ 8,500.00
10mM * 1mL in DMSO
¥ 1,000.00
Warning 产品仅用于科学研究,不针对患者销售,望谅解.

详情

GF 109203X is a potent and selective inhibitor of protein kinase C, selective for the α and β1 isoforms (IC50 values are 0.0084, 0.0180, 0.210, 0.132, and 5.8 μM for α, β1, δ, ε and ζ isoforms respectively). Selective over MLCK, PKG and PKA (IC50 values are 0.6, 4.6, and 33 μM respectively). Potent antagonist at the 5-HT3 receptor (Ki = 29.5 nM).
Targets
Target Value
PKCβ2IC50: 16nM
PKCβ1IC50: 17nM
PKCαIC50: 20nM
PKCγIC50: 20nM
PDGFRIC50: 65μM
EGFRIC50: >100μM
Insulin ReceptorIC50: >100μM
In vitro DMSO 82 mg/mL (198.79 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 24.24 mL 121.22 mL 242.43 mL
0.5 mM 4.85 mL 24.24 mL 48.49 mL
1 mM 2.42 mL 12.12 mL 24.24 mL
5 mM 0.48 mL 2.42 mL 4.85 mL

*The above data is based on the productmolecular weight 412.49. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Technical Details

目录号 A13197
MECHANISM OF ACTION Inhibitor
M. Wt 412.49
Formula C25H24N4O2
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 133052-90-1
Synonyms GF-109203X, GF109203X, GO6850, GO-6850, Bisindolylmaleimide I
SMILES CN(C)CCCN1C=C(C2=CC=CC=C21)C3=C(C(=O)NC3=O)C4=CNC5=CC=CC=C54

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