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GF 109203X

促销

PKC 抑制剂

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产品目录号: A13197

库存状态:中国现货中国现货

产品名 目录号 价格 数量
GF 109203X 10mg A13197-10
¥ 1,200.00
GF 109203X 25mg A13197-25
¥ 2,400.00
GF 109203X 50mg A13197-50
¥ 4,500.00
GF 109203X 100mg A13197-100
¥ 8,500.00
GF 109203X 10mM * 1mL in DMSO A13197-10mM-D
¥ 1,000.00

产品仅用于研究,不针对患者销售,望谅解.

产品简介

GF 109203X is a potent and selective inhibitor of protein kinase C, selective for the α and β1 isoforms (IC50 values are 0.0084, 0.0180, 0.210, 0.132, and 5.8 μM for α, β1, δ, ε and ζ isoforms respectively). Selective over MLCK, PKG and PKA (IC50 values are 0.6, 4.6, and 33 μM respectively). Potent antagonist at the 5-HT3 receptor (Ki = 29.5 nM).

GF 109203X

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Chemical Information

目录号 A13197
Mechanism of action Inhibitor
分子量 412.49
化学分子式 C25H24N4O2
Solubility DMSO
纯度 >98%
储存方式 at -20°C 2 years
CAS No. 133052-90-1
Synonyms GF-109203X, GF109203X, GO6850, GO-6850, Bisindolylmaleimide I
SMILES code CN(C)CCCN1C=C(C2=CC=CC=C21)C3=C(C(=O)NC3=O)C4=CNC5=CC=CC=C54
化学名称 2-[1-(3-Dimethylaminopropyl)indol-3?-yl]-3-(indol-3-yl) maleimide

生物活性

Description
GF 109203X is a potent and selective inhibitor of protein kinase C, selective for the α and β1 isoforms (IC50 values are 0.0084, 0.0180, 0.210, 0.132, and 5.8 μM for α, β1, δ, ε and ζ isoforms respectively). Selective over MLCK, PKG and PKA (IC50 values are 0.6, 4.6, and 33 μM respectively). Potent antagonist at the 5-HT3 receptor (Ki = 29.5 nM).
Targets
Target Value
PKCβ2IC50: 16nM
PKCβ1IC50: 17nM
PKCαIC50: 20nM
PKCγIC50: 20nM
PDGFRIC50: 65μM
EGFRIC50: >100μM
Insulin ReceptorIC50: >100μM

溶解性

Solubility (25°C)* In vitro DMSO 82 mg/mL (198.79 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 24.24 mL 121.22 mL 242.43mL
0.5 mM 4.85 mL 24.24 mL 48.49 mL
1 mM 2.42 mL 12.12 mL 24.24 mL
5 mM 0.48 mL 2.42 mL 4.85 mL

*The above data is based on the productmolecular weight 412.49. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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