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GGTI298 is a CAAZ peptidomimetic geranylgeranyltransferase I (GGTase I) inhibitor, strongly inhibiting the processing of geranylgeranylated Rap1A with little effect on processing of farnesylated Ha-Ras, with IC50 values of 3 and > 20 μM in vivo, respectively.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 20.85 mL | 104.25 mL | 208.49 mL |
| 0.5 mM | 4.17 mL | 20.85 mL | 41.7 mL |
| 1 mM | 2.08 mL | 10.42 mL | 20.85 mL |
| 5 mM | 0.42 mL | 2.08 mL | 4.17 mL |
*The above data is based on the productmolecular weight 479.63. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A20418 |
|---|---|
| M. Wt | 479.63 |
| Formula | C27H33N3O3S |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 180977-44-0 |
| Synonyms | GGTI 298, GGTI-298 |
| SMILES | CC(C)C[C@@H](C(OC)=O)NC(C1=CC=C(NC[C@@H](N)CS)C=C1C2=C3C=CC=CC3=CC=C2)=O |
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