Ginisortamab (UCB6114) is a fully human IgG4P monoclonal antibody targeting Gremlin-1. It demonstrates potent inhibitory activity with mean IC50 values of 8.2 nM and 9 nM against human and mouse Gremlin-1, respectively. By antagonizing Gremlin-1, Ginisortamab effectively disrupts the BMP signaling pathways, which are crucial in various biological processes including tissue growth and repair. This antibody holds significant potential for use in research focused on gastrointestinal (GI) tumors, providing a valuable tool for elucidating the role of Gremlin-1 in cancer pathogenesis and therapy.
Ginisortamab (UCB6114) is a fully human IgG4P monoclonal antibody targeting Gremlin-1. It demonstrates potent inhibitory activity with mean IC50 values of 8.2 nM and 9 nM against human and mouse Gremlin-1, respectively. By antagonizing Gremlin-1, Ginisortamab effectively disrupts the BMP signaling pathways, which are crucial in various biological processes including tissue growth and repair. This antibody holds significant potential for use in research focused on gastrointestinal (GI) tumors, providing a valuable tool for elucidating the role of Gremlin-1 in cancer pathogenesis and therapy.
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