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GLPG0634

促销

JAK1 抑制剂

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产品目录号: A13162

库存状态:中国现货中国现货

产品名 目录号 价格 数量
GLPG0634 5mg A13162-5
¥ 2,000.00
GLPG0634 10mg A13162-10
¥ 3,500.00
GLPG0634 25mg A13162-25
¥ 6,800.00
GLPG0634 50mg A13162-50
¥ 11,000.00

产品仅用于研究,不针对患者销售,望谅解.

产品简介

GLPG0634 is an orally-available, selective inhibitor of JAK1 (Janus kinase 1) being developed by Galapagos for the treatment of rheumatoid arthritis and potentially other inflammatory diseases.

GLPG0634

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顾客使用 Adooq 产品发表的高质量科研文献
Adooq 顾客使用 GLPG0634 发表的文献 (1)
  • Keisuke Nishimura, .et al. Tofacitinib facilitates the expansion of myeloid-derived suppressor cells and ameliorates arthritis in SKG mice., Arthritis Rheumatol., 2015, Apr;67(4):893-902 PMID: 25545152

Chemical Information

目录号 A13162
Mechanism of action Inhibitor
分子量 410.15
化学分子式 C23H18N6O2
Solubility DMSO
纯度 >98%
储存方式 at -20°C 2 years
CAS No. 1206101-20-3
Synonyms GLPG 0634, GLPG-0634
SMILES code c1cc(n2c(c1)nc(n2)NC(=O)C3CC3)c4ccc(cc4)OCc5ccc(nc5)C#N
化学名称 N/A

生物活性

Description
GLPG0634 is an orally-available, selective inhibitor of JAK1 (Janus kinase 1) being developed by Galapagos for the treatment of rheumatoid arthritis and potentially other inflammatory diseases.
Targets
JAK

溶解性

Solubility (25°C)* In vitro DMSO 0.1 mg/mL (<1 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 24.38 mL 121.91 mL 243.81mL
0.5 mM 4.88 mL 24.38 mL 48.76 mL
1 mM 2.44 mL 12.19 mL 24.38 mL
5 mM 0.49 mL 2.44 mL 4.88 mL

*The above data is based on the productmolecular weight 410.15. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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