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GLPG2451 is a cystic fibrosis transmembrane conductance regulator (CFTR) potentiator, which effectively potentiates low temperature rescued F508del CFTR with an EC50 of 11.1 nM.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 23.84 mL | 119.22 mL | 238.45 mL |
| 0.5 mM | 4.77 mL | 23.84 mL | 47.69 mL |
| 1 mM | 2.38 mL | 11.92 mL | 23.84 mL |
| 5 mM | 0.48 mL | 2.38 mL | 4.77 mL |
*The above data is based on the productmolecular weight 419.38. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A18919 |
|---|---|
| 作用机制 | Potentiator (增强剂) |
| M. Wt | 419.38 |
| Formula | C16H16F3N3O5S |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 2055015-61-5 |
| Synonyms | GLPG 2451, GLPG-2451 |
| SMILES | O=S(C1=CC=C(OC(F)(F)F)C=C1)(C2=CN=C(C(NC[C@@H](O)C)=O)C(N)=C2)=O |
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