Glycyrrhetinic acid (Enoxolone)
目录号: A10353
15-PGDH 抑制剂
甘草酸抑制了代谢前列腺素PGE-2和PGF-2α为其相应的15-酮-13,14-二氢代谢物(这些代谢物是无活性的)的酶(15-羟基前列腺素脱氢酶和delta-13-前列腺素)。
| Discription | Glycyrrhetinic acid inhibits the enzymes (15-hydroxyprostaglandin dehydrogenase and delta-13-prostaglandin) that metabolize the prostaglandins PGE-2 and PGF-2α to their respective 15-keto-13,14-dihydro metabolites which are inactive. | ||
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| 目录号 | A10353 |
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| 分子式 | C30H46O4 |
| 分子量 | 470.7 |
| CAS号 | 471-53-4 |
| SMILES | C[C@]12CC[C@](C[C@H]1C3=CC(=O)[C@@H]4[C@]5(CC[C@@H](C([C@@H]5CC[C@]4([C@@]3(CC2)C)C)(C)C)O)C)(C)C(=O)O |
| 其他名称 | Enoxolone, Glycyrrhetin, Uralenic acid, Glycyrrhetinate, Arthrodont |
| 储存条件 | Store lyophilized at -20ºC, keep desiccated. |
| In vitro (25°C) | DMSO | 85 mg/mL (180.59 mM) | |
| Water | Insoluble | ||
| Ethanol | Insoluble | ||
| In vivo | 2% DMSO+corn oil | 9 mg/mL | |
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* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
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| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 21.24 mL | 106.22 mL | 212.45 mL |
| 0.5 mM | 4.25 mL | 21.24 mL | 42.49 mL |
| 1 mM | 2.12 mL | 10.62 mL | 21.24 mL |
| 5 mM | 0.42 mL | 2.12 mL | 4.25 mL |
Calculate the dilution required to prepare a stock solution. This equation is commonly abbreviated as: C1V1 = C2V2