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Glycyrrhetinic acid (Enoxolone)

15-PGDH 抑制剂

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产品目录号: A10353

库存状态:中国现货中国现货

产品名 目录号 价格 数量
Glycyrrhetinic acid 500mg A10353-500
¥ 500.00
Glycyrrhetinic acid 2g A10353-2000
¥ 1,600.00
Glycyrrhetinic acid 10mM * 1mL in DMSO A10353-10mM-D
¥ 590.00

产品仅用于研究,不针对患者销售,望谅解.

产品简介

Glycyrrhetinic acid inhibits the enzymes (15-hydroxyprostaglandin dehydrogenase and delta-13-prostaglandin) that metabolize the prostaglandins PGE-2 and PGF-2α to their respective 15-keto-13,14-dihydro metabolites which are inactive.

Glycyrrhetinic acid (Enoxolone)

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Chemical Information

目录号 A10353
Mechanism of action Inhibitor
分子量 470.7
化学分子式 C30H46O4
Solubility DMSO
纯度 >98%
储存方式 at -20°C 2 years
CAS No. 471-53-4
Synonyms Enoxolone, Glycyrrhetin, Uralenic acid, Glycyrrhetinate, Arthrodont
SMILES code C[C@]12CC[C@](C[C@H]1C3=CC(=O)[C@@H]4[C@]5(CC[C@@H](C([C@@H]5CC[C@]4([C@@]3(CC2)C)C)(C)C)O)C)(C)C(=O)O
化学名称 3b-Hydroxy-11-oxo-18b,20b-olean-12-en-29-oic acid

生物活性

Description
Glycyrrhetinic acid inhibits the enzymes (15-hydroxyprostaglandin dehydrogenase and delta-13-prostaglandin) that metabolize the prostaglandins PGE-2 and PGF-2α to their respective 15-keto-13,14-dihydro metabolites which are inactive.
Targets
15-hydroxyprostaglandin dehydrogenase

溶解性

Solubility (25°C)* In vitro DMSO 94 mg/mL (199.71 mM)
Water <1 mg/mL (<1 mM)
Ethanol 94 mg/mL (199.71 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 21.24 mL 106.22 mL 212.45mL
0.5 mM 4.25 mL 21.24 mL 42.49 mL
1 mM 2.12 mL 10.62 mL 21.24 mL
5 mM 0.42 mL 2.12 mL 4.25 mL

*The above data is based on the productmolecular weight 470.7 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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