GNE 477
目录号: A14114
PI3K/mTOR 抑制剂
GNE-477 是一种高效的双重 PI3K/mTOR 抑制剂，其对 PI3Kα 的 IC50 为 4 nM，对 mTOR 的 Kiapp 为 21 nM。
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生物活性
| Discription | GNE-477 is a potent and efficacious dual PI3K/mTOR inhibitor with IC50 of 4 nM for PI3Kα, Kiapp is 21 nM for mTOR. | |||||
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产品信息
| 目录号 | A14114 |
|---|---|
| 分子式 | C21H28N8O3S2 |
| 分子量 | 504.64 |
| CAS号 | 1032754-81-6 |
| SMILES | CC1=C(SC2=C1N=C(N=C2N3CCOCC3)C4=CN=C(N=C4)N)CN5CCN(CC5)S(=O)(=O)C |
| 其他名称 | GNE-477,GNE477 |
| 储存条件 | Store lyophilized at -20ºC, keep desiccated. |
溶解性数据
| In vitro | DMSO | 24 mg/mL (47.56 mM) | |
| Water | Insoluble | ||
| Ethanol | Insoluble | ||
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* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
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Preparing Stock Solutions
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 19.82 mL | 99.08 mL | 198.16 mL |
| 0.5 mM | 3.96 mL | 19.82 mL | 39.63 mL |
| 1 mM | 1.98 mL | 9.91 mL | 19.82 mL |
| 5 mM | 0.4 mL | 1.98 mL | 3.96 mL |
Useful Calculator
Calculate the dilution required to prepare a stock solution. This equation is commonly abbreviated as: C1V1 = C2V2
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| 购买 1032754-81-6 | 1032754-81-6 供应商 | 1032754-81-6 花费 | 1032754-81-6 生产商 | 订购 1032754-81-6 | 1032754-81-6 代理商