- Tanimizu N, .et al. Intrahepatic bile ducts guide establishment of the intrahepatic nerve network in developing and regenerating mouse liver, Development, 2018, Apr 25;145(9). pii: dev159095 PMID: 29615468
- Shargh VH, .et al. Gelatin-albumin hybrid nanoparticles as matrix metalloproteinases-degradable delivery systems for breast cancer therapy, Nanomedicine (Lond), 2017, May;12(9):977-989 PMID: 28440712
- Shargh VH, .et al. Albumin hybrid nanoparticles loaded with tyrosine kinase A inhibitor GNF-5837 for targeted inhibition of breast cancer cell growth and invasion, Int J Pharm, 2016, Dec 30;515(1-2):527-534 PMID: 27793712
|Mechanism of action||Inhibitor|
|储存方式||at -20°C 2 years|
|GNF-5837 is a potent, selective, and orally bioavailable pan-TRK inhibitor that inhibited tumor growth in a mouse xenograft model derived from RIE cells expressing both TRKA and NGF.|
|Solubility (25°C)*||In vitro||DMSO||100 mg/mL (186.74 mM)|
|Water||<1 mg/mL (<1 mM)|
|Ethanol||9 mg/mL heating (16.8 mM)|
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.1 mM||18.67 mL||93.37 mL||186.74mL|
|0.5 mM||3.73 mL||18.67 mL||37.35 mL|
|1 mM||1.87 mL||9.34 mL||18.67 mL|
|5 mM||0.37 mL||1.87 mL||3.73 mL|
*The above data is based on the productmolecular weight 535.49. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
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