GNF 5837

目录号: A13730

TRK inhibitor

GNF 5837

GNF 5837 Chemical Structure

CAS NO. 1033769-28-6

GNF-5837 is a potent, selective, and orally bioavailable pan-TRK inhibitor that inhibited tumor growth in a mouse xenograft model derived from RIE cells expressing both TRKA and NGF.

库存: 现货

规格 价格 数量
10 mg
¥ 1,000.00
25 mg
¥ 1,900.00
50 mg
¥ 2,700.00
100 mg
¥ 4,500.00
10mM * 1mL in DMSO
¥ 800.00
Warning 产品仅用于科学研究,不针对患者销售,望谅解.

详情

GNF-5837 is a potent, selective, and orally bioavailable pan-TRK inhibitor that inhibited tumor growth in a mouse xenograft model derived from RIE cells expressing both TRKA and NGF.
Targets
Target Value
TrkCIC50: 7nM
TrkBIC50: 9nM
TrkAIC50: 11nM
PDGFRβIC50: 0.87μM
KitIC50: 0.91μM
JAK2IC50: 2.9μM
ALKIC50: 3.4μM
CSF-1RIC50: 4μM
FLT3IC50: 5.1μM
RETIC50: 5.3μM
MetIC50: 5.8μM
FGFR4IC50: 7μM
SrcIC50: 7.3μM
IGF-1RIC50: 7.6μM
Insulin ReceptorIC50: 8μM
AblIC50: 8.2μM
FGFR3IC50: 9.3μM
In vitro DMSO 100 mg/mL (186.74 mM)
Water <1 mg/mL (<1 mM)
Ethanol 9 mg/mL heating (16.8 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 18.67 mL 93.37 mL 186.74 mL
0.5 mM 3.73 mL 18.67 mL 37.35 mL
1 mM 1.87 mL 9.34 mL 18.67 mL
5 mM 0.37 mL 1.87 mL 3.73 mL

*The above data is based on the productmolecular weight 535.49. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

目录号 A13730
MECHANISM OF ACTION Inhibitor
M. Wt 535.49
Formula C28H21F4N5O2
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 1033769-28-6
Synonyms GNF-5837, GNF5837
SMILES CC1=C(C=C(C=C1)NC(=O)NC2=C(C=CC(=C2)C(F)(F)F)F)NC3=CC4=C(C=C3)/C(=C/C5=CC=CN5)/C(=O)N4

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