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GNF 5837

促销

TRK 抑制剂

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产品目录号: A13730

库存状态:中国现货中国现货

产品名 目录号 价格 数量
GNF 5837 10mg A13730-10
¥ 1,000.00
GNF 5837 25mg A13730-25
¥ 1,900.00
GNF 5837 50mg A13730-50
¥ 2,700.00
GNF 5837 100mg A13730-100
¥ 4,500.00
GNF 5837 10mM * 1mL in DMSO A13730-10mM-D
¥ 800.00

产品仅用于研究,不针对患者销售,望谅解.

产品简介

GNF-5837 is a potent, selective, and orally bioavailable pan-TRK inhibitor that inhibited tumor growth in a mouse xenograft model derived from RIE cells expressing both TRKA and NGF.

GNF 5837

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顾客使用 Adooq 产品发表的高质量科研文献
Adooq 顾客使用 GNF 5837 发表的文献 (3)
  • Tanimizu N, .et al. Intrahepatic bile ducts guide establishment of the intrahepatic nerve network in developing and regenerating mouse liver, Development, 2018, Apr 25;145(9). pii: dev159095 PMID: 29615468
  • Shargh VH, .et al. Gelatin-albumin hybrid nanoparticles as matrix metalloproteinases-degradable delivery systems for breast cancer therapy, Nanomedicine (Lond), 2017, May;12(9):977-989 PMID: 28440712
  • Shargh VH, .et al. Albumin hybrid nanoparticles loaded with tyrosine kinase A inhibitor GNF-5837 for targeted inhibition of breast cancer cell growth and invasion, Int J Pharm, 2016, Dec 30;515(1-2):527-534 PMID: 27793712

Chemical Information

目录号 A13730
Mechanism of action Inhibitor
分子量 535.49
化学分子式 C28H21F4N5O2
Solubility DMSO
纯度 >98%
储存方式 at -20°C 2 years
CAS No. 1033769-28-6
Synonyms GNF-5837, GNF5837
SMILES code CC1=C(C=C(C=C1)NC(=O)NC2=C(C=CC(=C2)C(F)(F)F)F)NC3=CC4=C(C=C3)/C(=C/C5=CC=CN5)/C(=O)N4
化学名称 (Z)-1-(3-((3-((1H-pyrrol-2-yl)methylene)-2-oxoindolin-6-yl)amino)-4-methylphenyl)-3-(2-fluoro-5-(trifluoromethyl)phenyl)urea

生物活性

Description
GNF-5837 is a potent, selective, and orally bioavailable pan-TRK inhibitor that inhibited tumor growth in a mouse xenograft model derived from RIE cells expressing both TRKA and NGF.
Targets
Target Value
TrkCIC50: 7nM
TrkBIC50: 9nM
TrkAIC50: 11nM
PDGFRβIC50: 0.87μM
KitIC50: 0.91μM
JAK2IC50: 2.9μM
ALKIC50: 3.4μM
CSF-1RIC50: 4μM
FLT3IC50: 5.1μM
RETIC50: 5.3μM
MetIC50: 5.8μM
FGFR4IC50: 7μM
SrcIC50: 7.3μM
IGF-1RIC50: 7.6μM
Insulin ReceptorIC50: 8μM
AblIC50: 8.2μM
FGFR3IC50: 9.3μM

溶解性

Solubility (25°C)* In vitro DMSO 100 mg/mL (186.74 mM)
Water <1 mg/mL (<1 mM)
Ethanol 9 mg/mL heating (16.8 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 18.67 mL 93.37 mL 186.74mL
0.5 mM 3.73 mL 18.67 mL 37.35 mL
1 mM 1.87 mL 9.34 mL 18.67 mL
5 mM 0.37 mL 1.87 mL 3.73 mL

*The above data is based on the productmolecular weight 535.49. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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