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Bcr-Abl 抑制剂

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产品目录号: A15887


产品名 目录号 价格 数量
GNF-7 5mg A15887-5
¥ 1,100.00
GNF-7 10mg A15887-10
¥ 2,000.00
GNF-7 25mg A15887-25
¥ 4,000.00



GNF-7 is a potent type-II kinase Bcr-Abl inhibitor with IC50 of <5 nM, 61 nM, 122 nM, 136 nM, and 133 nM for M351T, T315I, E255 V, G250E, and c-Abl, respectively.





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Chemical Information

目录号 A15887
Mechanism of action Inhibitor
分子量 547.53
化学分子式 C28H24F3N7O2
Solubility DMSO
纯度 >98%
储存方式 at -20°C 2 years
CAS No. 839706-07-9
Synonyms GNF7, GNF 7
SMILES code O=C(NC1=CC=C(C)C(N2CC3=CN=C(NC4=CC=C(C)N=C4)N=C3N(C)C2=O)=C1)C5=CC=CC(C(F)(F)F)=C5
化学名称 Benzamide, N-[3-[1,4-dihydro-1-methyl-7-[(6-methyl-3-pyridinyl)amino]-2-oxopyrimido[4,5-d]pyrimidin-3(2H)-yl]-4-methylphenyl]-3-(trifluoromethyl)-


GNF-7 is a potent type-II kinase Bcr-Abl inhibitor with IC50 of <5 nM, 61 nM, 122 nM, 136 nM, and 133 nM for M351T, T315I, E255 V, G250E, and c-Abl, respectively.
M351T T315I E255V c-Abl G250E
<5 nM61 nM122 nM133 nM136 nM


Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 18.26 mL 91.32 mL 182.64mL
0.5 mM 3.65 mL 18.26 mL 36.53 mL
1 mM 1.83 mL 9.13 mL 18.26 mL
5 mM 0.37 mL 1.83 mL 3.65 mL

*The above data is based on the productmolecular weight 547.53. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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