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Grazoprevir

Grazoprevir

Name: Grazoprevir
SKU: A17303

目录号: A17303

Hepatitis C virus NS3/4a protease inhibitor

Grazoprevir Chemical Structure

CAS NO. 1350514-68-9

Grazoprevir (MK-5172) is a selective inhibitor of Hepatitis C virus NS3/4a protease with broad activity across genotypes and resistant variants, with Kis of 0.01 nM (gt1b), 0.01 nM (gt1a), 0.08 nM (gt2a), 0.15 nM (gt2b), 0.90 nM (gt3a), respectively.

库存：现货

规格	价格	数量
5 mg	￥ 900.00
10 mg	￥ 1,550.00
50 mg	￥ 4,600.00
100 mg	￥ 9,200.00

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产品详情

生物活性

溶解度 *

In vitro	DMSO	93 mg/mL (121.26 mM)
	Water	Insoluble
	Ethanol	93 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	13.04 mL	65.2 mL	130.4 mL
0.5 mM	2.61 mL	13.04 mL	26.08 mL
1 mM	1.3 mL	6.52 mL	13.04 mL
5 mM	0.26 mL	1.3 mL	2.61 mL

*The above data is based on the productmolecular weight 766.9. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

化学数据

目录号	A17303
作用机制	Inhibitor (抑制剂)
M. Wt	766.9
Formula	C38H50N6O9S
Purity	>99%
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
CAS No.	1350514-68-9
Synonyms	MK-5172, MK5172, MK 5172
SMILES	COC1=CC2=C(N=C(CCCCC[C@@H]3C[C@H]3OC4=O)C(O[C@H]5CN(C([C@H](C(C)(C)C)N4)=O)[C@H](C(N[C@@]([C@@H]6C=C)(C6)C(NS(C7CC7)(=O)=O)=O)=O)C5)=N2)C=C1