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GSK 5959是一种有效的，选择性的且可透过细胞的BRPF1溴结构域抑制剂，IC50?80 nM。在35个其他溴结构域（包括BRPF2/3和BET家族溴结构域）中，对BRPF1的选择性超过100倍。
| In vitro | DMSO | 5 mg/mL (12.68 mM) | |
| Water | Insoluble | ||
| Ethanol | 3 mg/mL (7.6 mM) | ||
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
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| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 25.35 mL | 126.75 mL | 253.5 mL |
| 0.5 mM | 5.07 mL | 25.35 mL | 50.7 mL |
| 1 mM | 2.53 mL | 12.67 mL | 25.35 mL |
| 5 mM | 0.51 mL | 2.53 mL | 5.07 mL |
*The above data is based on the productmolecular weight 394.48. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A16092 |
|---|---|
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 394.48 |
| Formula | C22H26N4O3 |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 901245-65-6 |
| Synonyms | GSK-5959, GSK5959 |
| SMILES | O=C(NC1=C(N2CCCCC2)C=C(N3C)C(N(C)C3=O)=C1)C4=CC=CC=C4OC |
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