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GSK 650394是一种糖皮质激素和血清调节激酶1（SGK1）抑制剂，对LNCaP前列腺癌细胞系表现出抗增殖特性。
靶点信息
| SGK1 | SGK2 | |||
| 62 nM | 103 nM |
| In vitro | DMSO | 72 mg/mL (188.25 mM) | |
| Water | Insoluble | ||
| Ethanol | Insoluble | ||
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 26.15 mL | 130.74 mL | 261.47 mL |
| 0.5 mM | 5.23 mL | 26.15 mL | 52.29 mL |
| 1 mM | 2.61 mL | 13.07 mL | 26.15 mL |
| 5 mM | 0.52 mL | 2.61 mL | 5.23 mL |
*The above data is based on the productmolecular weight 382.45. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A13309 |
|---|---|
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 382.45 |
| Formula | C25H22N2O2 |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 890842-28-1 |
| Synonyms | GSK 650394, GSK650394 |
| SMILES | C1CCC(C1)C2=C(C=CC(=C2)C3=CNC4=NC=C(C=C34)C5=CC=CC=C5)C(=O)O |
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