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GSK J4是可被细胞吞噬的前药，可被巨噬细胞酯酶快速水解为GSK-J1，GSK-J1是一种有效的选择性Jumonji H3K27脱甲基酶抑制剂。 减轻脂多糖（LPS）诱导的人类原代巨噬细胞促炎细胞因子的产生（IC50 = 9 uM，抑制TNFα释放）。
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 23.95 mL | 119.76 mL | 239.52 mL |
| 0.5 mM | 4.79 mL | 23.95 mL | 47.9 mL |
| 1 mM | 2.4 mL | 11.98 mL | 23.95 mL |
| 5 mM | 0.48 mL | 2.4 mL | 4.79 mL |
*The above data is based on the productmolecular weight 417.5. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A12732 |
|---|---|
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 417.5 |
| Formula | C24H27N5O2 |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 1373423-53-0 |
| Synonyms | GSK J4 |
| SMILES | CCOC(=O)CCNC1=NC(=NC(=C1)N2CCC3=CC=CC=C3CC2)C4=CC=CC=N4 |
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