GSK-J4

目录号: A12732

Demethylase Inhibitor

GSK-J4

GSK-J4 Chemical Structure

CAS NO. 1373423-53-0

GSK J4 is a cell permeable prodrug rapidly hydrolyzed by macrophage esterases to GSK-J1, a potent selective jumonji H3K27 demethylase inhibitor; attenuates lipopolysaccharide (LPS)-induced proinflammatory cytokine production in primary human macrophages (IC50 = 9 uM for the inhibition of TNF?? release).

库存: 现货

规格 价格 数量
10 mg
¥ 1,200.00
25 mg
¥ 2,500.00
50 mg
¥ 3,500.00
Warning 产品仅用于科学研究,不针对患者销售,望谅解.

详情

GSK J4 is a cell permeable prodrug rapidly hydrolyzed by macrophage esterases to GSK-J1, a potent selective jumonji H3K27 demethylase inhibitor; attenuates lipopolysaccharide (LPS)-induced proinflammatory cytokine production in primary human macrophages (IC50 = 9 uM for the inhibition of TNF?? release).
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 23.95 mL 119.76 mL 239.52 mL
0.5 mM 4.79 mL 23.95 mL 47.9 mL
1 mM 2.4 mL 11.98 mL 23.95 mL
5 mM 0.48 mL 2.4 mL 4.79 mL

*The above data is based on the productmolecular weight 417.5. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

目录号 A12732
MECHANISM OF ACTION Inhibitor
M. Wt 417.5
Formula C24H27N5O2
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 1373423-53-0
Synonyms GSK J4
SMILES CCOC(=O)CCNC1=NC(=NC(=C1)N2CCC3=CC=CC=C3CC2)C4=CC=CC=N4

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