GSK-J4

Name: GSK-J4
SKU: A12732
Price: 315 CNY
Rating: 5 (1 reviews)

目录号: A12732

Demethylase 抑制剂

1 篇发表文献

GSK J4 是一种细胞渗透性前药，可被巨噬细胞酯酶迅速水解为 GSK-J1，后者是一种强效的选择性 jumonji H3K27 去甲基化酶抑制剂；它能减弱脂多糖（LPS）诱导的原发性人类巨噬细胞中的促炎细胞因子产生（IC50 = 9 uM，用于抑制 TNFα 发布）。

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Grouped product items
规格	价格	库存
2mg	¥315.00	现货
5mg	¥525.00	现货
10mg	¥910.00	现货
25mg	¥1,400.00	现货
50mg	¥2,520.00	现货
100mg	¥4,025.00	现货
200mg	¥5,110.00	现货
*10mM 1mL in DMSO**	¥945.00	现货
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重要通知：仅供研究使用。我们不向患者销售。

Data Sheet

SDS

顾客使用 Adooq 产品发表的高质量科研文献

Adooq用户使用GSK-J4发表的1篇文献

Guang Bai, .et al. , Epigenetics of Chronic Pain, 2019, Pages 1-48

生物活性

Discription	GSK J4 is a cell permeable prodrug rapidly hydrolyzed by macrophage esterases to GSK-J1, a potent selective jumonji H3K27 demethylase inhibitor; attenuates lipopolysaccharide (LPS)-induced proinflammatory cytokine production in primary human macrophages (IC50 = 9 uM for the inhibition of TNF?? release).

产品信息

目录号	A12732
分子式	C24H27N5O2
分子量	417.5
CAS号	1373423-53-0
SMILES	CCOC(=O)CCNC1=NC(=NC(=C1)N2CCC3=CC=CC=C3CC2)C4=CC=CC=N4
其他名称	GSK J4
储存条件	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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