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GSK046 (iBET-BD2) is a potent, selective and orally active BD2 bromodomain inhibitor of the BET proteins, with IC50s of 264 nM (BRD2 BD2), 98 nM (BRD3 BD2), 49 nM (BRD4 BD2) and 214 nM (BRDT BD2), respectively.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 24.13 mL | 120.64 mL | 241.27 mL |
| 0.5 mM | 4.83 mL | 24.13 mL | 48.25 mL |
| 1 mM | 2.41 mL | 12.06 mL | 24.13 mL |
| 5 mM | 0.48 mL | 2.41 mL | 4.83 mL |
*The above data is based on the productmolecular weight 414.47. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A22068 |
|---|---|
| M. Wt | 414.47 |
| Formula | C23H27FN2O4 |
| Solubility | DMSO |
| Purity | >98% |
| Storage | at -20°C 2 years |
| CAS No. | 2474876-09-8 |
| Synonyms | iBET-BD2 |
| SMILES | O=C(N[C@H]1CC[C@H](O)CC1)C2=CC(O[C@H](C3=CC=CC=C3)C)=C(NC(C)=O)C(F)=C2 |
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