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GSK1059615

促销

mTOR/PI3K 抑制剂

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产品目录号: A10438

库存状态:中国现货中国现货

产品名 目录号 价格 数量
GSK1059615 5mg A10438-5
¥ 700.00
GSK1059615 10mg A10438-10
¥ 1,200.00
GSK1059615 25mg A10438-25
¥ 2,500.00
GSK1059615 50mg A10438-50
¥ 4,500.00

产品仅用于研究,不针对患者销售,望谅解.

产品简介

GSK1059615 is a potent, reversible, ATP-competitive, thiazolidinedione inhibitor of PI3Kα (IC50 = 2 nM).

GSK1059615

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顾客使用 Adooq 产品发表的高质量科研文献
Adooq 顾客使用 GSK1059615 发表的文献 (1)
  • Jing Xie, .et al. GSK1059615 kills head and neck squamous cell carcinoma cells possibly via activating mitochondrial programmed necrosis pathway, Oncotarget, 2017, Aug 1; 8(31): 50814每50823 PMID: 28881606

Chemical Information

目录号 A10438
Mechanism of action Inhibitor
分子量 333.4
化学分子式 C18H11N3O2S
Solubility DMSO
纯度 >98%
储存方式 at -20°C 2 years
CAS No. 958852-01-2
Synonyms GSK-1059615
SMILES code C1=CC2=NC=CC(=C2C=C1/C=C\3/C(=O)NC(=O)S3)C4=CC=NC=C4
化学名称 5-[[4-(4-Pyridinyl)-6-quinolinyl]methylene]-2,4-thiazolidenedione

生物活性

Description
GSK1059615 is a potent, reversible, ATP-competitive, thiazolidinedione inhibitor of PI3Kα (IC50 = 2 nM).
Targets
PI3Kα PI3Kβ PI3Kδ PI3Kγ mTOR
0.4 nM0.6 nM2 nM5 nM12 nM

溶解性

Solubility (25°C)* In vitro DMSO 2 mg/mL (5.99 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 29.99 mL 149.97 mL 299.94mL
0.5 mM 6 mL 29.99 mL 59.99 mL
1 mM 3 mL 15 mL 29.99 mL
5 mM 0.6 mL 3 mL 6 mL

*The above data is based on the productmolecular weight 333.4 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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